Combatting the evolution of antifungal resistance in Cryptococcus neoformans
A Bermas, J Geddes‐McAlister - Molecular microbiology, 2020 - Wiley Online Library
Fungal infections are a global concern and the evolution of intrinsic resistance to current
antifungals presents an alarming problem. For Cryptococcus neoformans, a human fungal …
antifungals presents an alarming problem. For Cryptococcus neoformans, a human fungal …
New pathogens, new tricks: emerging, drug‐resistant fungal pathogens and future prospects for antifungal therapeutics
J Geddes‐McAlister, RS Shapiro - … of the New York Academy of …, 2019 - Wiley Online Library
Fungal pathogens are a growing threat to public health. As human immunodeficiency
becomes increasingly common, fungal infections are becoming more prevalent. The use of …
becomes increasingly common, fungal infections are becoming more prevalent. The use of …
A One Health approach to overcoming fungal disease and antifungal resistance
M Woods, JA McAlister… - WIREs Mechanisms of …, 2023 - Wiley Online Library
The global burden of fungal disease poses a substantial threat to human, animal, and
environmental health, endangering both human and livestock populations and creating …
environmental health, endangering both human and livestock populations and creating …
Comparison of healthy and dandruff scalp microbiome reveals the role of commensals in scalp health
Several scalp microbiome studies from different populations have revealed the association
of dandruff with bacterial and fungal dysbiosis. However, the functional role of scalp …
of dandruff with bacterial and fungal dysbiosis. However, the functional role of scalp …
Titan cells formation in Cryptococcus neoformans is finely tuned by environmental conditions and modulated by positive and negative genetic regulators
B Hommel, L Mukaremera, RJB Cordero… - PLoS …, 2018 - journals.plos.org
The pathogenic fungus Cryptococcus neoformans exhibits morphological changes in cell
size during lung infection, producing both typical size 5 to 7 μm cells and large titan cells (> …
size during lung infection, producing both typical size 5 to 7 μm cells and large titan cells (> …
Cryptococcus neoformans can form titan-like cells in vitro in response to multiple signals
N Trevijano-Contador, HC de Oliveira… - PLoS …, 2018 - journals.plos.org
Cryptococcus neoformans is an encapsulated pathogenic yeast that can change the size of
the cells during infection. In particular, this process can occur by enlarging the size of the …
the cells during infection. In particular, this process can occur by enlarging the size of the …
The cAMP/Protein Kinase A Pathway Regulates Virulence and Adaptation to Host Conditions in Cryptococcus neoformans
M Caza, JW Kronstad - Frontiers in cellular and infection microbiology, 2019 - frontiersin.org
Nutrient sensing is critical for adaptation of fungi to environmental and host conditions. The
conserved cAMP/PKA signaling pathway contributes to adaptation by sensing the …
conserved cAMP/PKA signaling pathway contributes to adaptation by sensing the …
Fun (gi) omics: Advanced and diverse technologies to explore emerging fungal pathogens and define mechanisms of antifungal resistance
B Ball, M Langille, J Geddes-McAlister - MBio, 2020 - Am Soc Microbiol
The landscape of infectious fungal agents includes previously unidentified or rare
pathogens with the potential to cause unprecedented casualties in biodiversity, food …
pathogens with the potential to cause unprecedented casualties in biodiversity, food …
Post-translational modifications drive success and failure of fungal–host interactions
C Retanal, B Ball, J Geddes-McAlister - Journal of Fungi, 2021 - mdpi.com
Post-translational modifications (PTMs) change the structure and function of proteins and
regulate a diverse array of biological processes. Fungal pathogens rely on PTMs to …
regulate a diverse array of biological processes. Fungal pathogens rely on PTMs to …
Comparative Cross-Kingdom DDA-and DIA-PASEF Proteomic Profiling Reveals Novel Determinants of Fungal Virulence and a Putative Druggable Target
B Ball, A Sukumaran, JR Krieger… - Journal of Proteome …, 2024 - ACS Publications
Accurate and reliable detection of fungal pathogens presents an important hurdle to manage
infections, especially considering that fungal pathogens, including the globally important …
infections, especially considering that fungal pathogens, including the globally important …