Combatting the evolution of antifungal resistance in Cryptococcus neoformans

A Bermas, J Geddes‐McAlister - Molecular microbiology, 2020 - Wiley Online Library
Fungal infections are a global concern and the evolution of intrinsic resistance to current
antifungals presents an alarming problem. For Cryptococcus neoformans, a human fungal …

New pathogens, new tricks: emerging, drug‐resistant fungal pathogens and future prospects for antifungal therapeutics

J Geddes‐McAlister, RS Shapiro - … of the New York Academy of …, 2019 - Wiley Online Library
Fungal pathogens are a growing threat to public health. As human immunodeficiency
becomes increasingly common, fungal infections are becoming more prevalent. The use of …

A One Health approach to overcoming fungal disease and antifungal resistance

M Woods, JA McAlister… - WIREs Mechanisms of …, 2023 - Wiley Online Library
The global burden of fungal disease poses a substantial threat to human, animal, and
environmental health, endangering both human and livestock populations and creating …

Comparison of healthy and dandruff scalp microbiome reveals the role of commensals in scalp health

R Saxena, P Mittal, C Clavaud, DB Dhakan… - Frontiers in cellular …, 2018 - frontiersin.org
Several scalp microbiome studies from different populations have revealed the association
of dandruff with bacterial and fungal dysbiosis. However, the functional role of scalp …

Titan cells formation in Cryptococcus neoformans is finely tuned by environmental conditions and modulated by positive and negative genetic regulators

B Hommel, L Mukaremera, RJB Cordero… - PLoS …, 2018 - journals.plos.org
The pathogenic fungus Cryptococcus neoformans exhibits morphological changes in cell
size during lung infection, producing both typical size 5 to 7 μm cells and large titan cells (> …

Cryptococcus neoformans can form titan-like cells in vitro in response to multiple signals

N Trevijano-Contador, HC de Oliveira… - PLoS …, 2018 - journals.plos.org
Cryptococcus neoformans is an encapsulated pathogenic yeast that can change the size of
the cells during infection. In particular, this process can occur by enlarging the size of the …

The cAMP/Protein Kinase A Pathway Regulates Virulence and Adaptation to Host Conditions in Cryptococcus neoformans

M Caza, JW Kronstad - Frontiers in cellular and infection microbiology, 2019 - frontiersin.org
Nutrient sensing is critical for adaptation of fungi to environmental and host conditions. The
conserved cAMP/PKA signaling pathway contributes to adaptation by sensing the …

Fun (gi) omics: Advanced and diverse technologies to explore emerging fungal pathogens and define mechanisms of antifungal resistance

B Ball, M Langille, J Geddes-McAlister - MBio, 2020 - Am Soc Microbiol
The landscape of infectious fungal agents includes previously unidentified or rare
pathogens with the potential to cause unprecedented casualties in biodiversity, food …

Post-translational modifications drive success and failure of fungal–host interactions

C Retanal, B Ball, J Geddes-McAlister - Journal of Fungi, 2021 - mdpi.com
Post-translational modifications (PTMs) change the structure and function of proteins and
regulate a diverse array of biological processes. Fungal pathogens rely on PTMs to …

Comparative Cross-Kingdom DDA-and DIA-PASEF Proteomic Profiling Reveals Novel Determinants of Fungal Virulence and a Putative Druggable Target

B Ball, A Sukumaran, JR Krieger… - Journal of Proteome …, 2024 - ACS Publications
Accurate and reliable detection of fungal pathogens presents an important hurdle to manage
infections, especially considering that fungal pathogens, including the globally important …