Drug therapy for stable angina pectoris

TA Rousan, ST Mathew, U Thadani - Drugs, 2017 - Springer
Chronic stable angina pectoris refers to the predictable, reproducible occurrence of pressure
or a choking sensation in the chest or adjacent areas caused by myocardial ischemia in …

[HTML][HTML] Probing the interactions of 31 mycotoxins with xanthine oxidase: alternariol, alternariol-3-sulfate, and α-zearalenol are allosteric inhibitors of the enzyme

O Balázs, Á Dombi, BZ Zsidó, C Hetényi, RG Vida… - Toxins, 2023 - mdpi.com
Mycotoxins are frequent toxic contaminants in foods and beverages, causing a significant
health threat. Interactions of mycotoxins with biotransformation enzymes (eg, cytochrome …

[HTML][HTML] Stable angina medical therapy management guidelines: a critical review of guidelines from the European Society of Cardiology and National Institute for …

TA Rousan, U Thadani - European Cardiology Review, 2019 - ncbi.nlm.nih.gov
Most patients with stable angina can be managed with lifestyle changes, especially smoking
cessation and regular exercise, along with taking antianginal drugs. Randomised controlled …

Anti‐nociceptive properties of the xanthine oxidase inhibitor allopurinol in mice: role of A1 adenosine receptors

AP Schmidt, AE Böhmer, C Antunes… - British journal of …, 2009 - Wiley Online Library
Background and purpose: Allopurinol is a potent inhibitor of the enzyme xanthine oxidase,
used primarily in the treatment of hyperuricemia and gout. It is well known that purines exert …

[HTML][HTML] Effect of allopurinol in addition to hypothermia treatment in neonates for hypoxic-ischemic brain injury on neurocognitive outcome (ALBINO): study protocol of …

CA Maiwald, KV Annink, M Rüdiger, MJNL Benders… - BMC pediatrics, 2019 - Springer
Background Perinatal asphyxia and resulting hypoxic-ischemic encephalopathy is a major
cause of death and long-term disability in term born neonates. Up to 20,000 infants each …

Predicting allopurinol response in patients with gout

DFB Wright, SB Duffull, TR Merriman… - British journal of …, 2016 - Wiley Online Library
Aims The primary aim of this research was to predict the allopurinol maintenance doses
required to achieve the target plasma urate of≤ 0.36 mmol l− 1. Methods A population …

Oxypurinol–a novel marker for wastewater contamination of the aquatic environment

J Funke, C Prasse, CL Eversloh, TA Ternes - Water research, 2015 - Elsevier
The anti-gout agent allopurinol is one of the most prescribed pharmaceuticals in Germany
and is widely metabolized into oxypurinol (80%) as well as the corresponding riboside …

[HTML][HTML] Low-dose azathioprine in combination with allopurinol: the past, present and future of this useful duo

AK Turbayne, MP Sparrow - Digestive Diseases and Sciences, 2022 - Springer
The inflammatory bowel diseases (IBD) are complex immune-mediated inflammatory
diseases that are associated with significant morbidity around the world. As our …

Allopurinol: old drug, new indication in neonates?

KV Annink, AR Franz, JB Derks… - Current …, 2017 - ingentaconnect.com
Background: Hypoxic-ischemic encephalopathy (HIE) is an important cause of neonatal
mortality and neurological morbidity, even despite hypothermia treatment. Neuronal damage …

Pharmacokinetic and pharmacodynamic interaction between allopurinol and probenecid in patients with gout

SL Stocker, GG Graham, AJ McLachlan… - The Journal of …, 2011 - jrheum.org
Objective. To investigate the pharmacokinetic and pharmacodynamic interaction between
probenecid and oxypurinol (the active metabolite of allopurinol) in patients with gout …