CeRebrUm and CardIac Protection with ALlopurinol in Neonates with Critical Congenital Heart Disease Requiring Cardiac Surgery with Cardiopulmonary Bypass …

R Stegeman, M Nijman, JMPJ Breur, F Groenendaal… - Trials, 2022 - Springer
Background Neonates with critical congenital heart disease (CCHD) undergoing cardiac
surgery with cardiopulmonary bypass (CPB) are at risk of brain injury that may result in …

Efficacy and safety of febuxostat in the treatment of hyperuricemia in stable kidney transplant recipients

T Sofue, M Inui, T Hara, Y Nishijima… - Drug design …, 2014 - Taylor & Francis
Background Post-transplant hyperuricemia (PTHU), defined as serum uric acid
concentration≥ 7.0 mg/dL or need for treatment with allopurinol or benzbromarone, reduces …

Allopurinol non-covalently facilitates binding of unconventional peptides to HLA-B* 58: 01

X Huan, N Zhuo, HY Lee, EC Ren - Scientific Reports, 2023 - nature.com
Allopurinol, widely used in gout treatment, is the most common cause of severe cutaneous
adverse drug reactions. The risk of developing such life-threatening reactions is increased …

Atractylodin inhibits fructose-induced human podocyte hypermotility via anti-oxidant to down-regulate TRPC6/p-CaMK4 signaling

L Chen, YL Tang, ZH Liu, Y Pan, RQ Jiao… - European Journal of …, 2021 - Elsevier
High fructose has been reported to drive glomerular podocyte oxidative stress and then
induce podocyte foot process effacement in vivo, which could be partly regarded as …

Allopurinol augmentation in acute mania: a meta-analysis of placebo-controlled trials

AT Chen, T Malmstrom, HA Nasrallah - Journal of affective disorders, 2018 - Elsevier
Background Allopurinol is a xanthine oxidase inhibitor commonly used in the treatment of
gout. Recent studies have also shown its promise as an adjunctive treatment for manic …

[HTML][HTML] Occurrence, fate and potential risks of pharmaceuticals and personal care products (PPCPs) in Elbe river water during water treatment in Dresden, Germany

Y Adomat, T Grischek - Environmental Challenges, 2024 - Elsevier
Pharmaceuticals and personal care products (PPCPs) are found in most rivers facing
sewage input worldwide. This study investigated the occurence of 116 PPCPs in the Elbe …

How much allopurinol does it take to get to target urate? Comparison of actual dose with creatinine clearance-based dose

LK Stamp, PT Chapman, ML Barclay, A Horne… - Arthritis research & …, 2018 - Springer
Objective Allopurinol dosing has frequently been limited based on creatinine clearance
(CrCL), resulting in failure to achieve target serum urate (SU). The aim of this analysis was to …

Allopurinol attenuates postoperative pain and modulates the purinergic system in patients undergoing abdominal hysterectomy: a randomized controlled trial

AP Schmidt, ED de Oliveira, AC Fagundes… - Journal of …, 2021 - Springer
Purpose Allopurinol is a potent inhibitor of the enzyme xanthine oxidase used primarily in
the treatment of hyperuricemia and gout. The aim of this study was to compare the analgesic …

Pharmacokinetic and pharmacodynamic interaction between allopurinol and probenecid in healthy subjects

SL Stocker, KM Williams, AJ McLachlan… - Clinical …, 2008 - Springer
Background and objective: Combination therapy with allopurinol and probenecid is used to
treat tophaceous gout in patients who do not respond sufficiently to allopurinol alone …

Cleroda-4(18),13-dien-15,16-olide as novel xanthine oxidase inhibitors: An integrated in silico and in vitro study

HT Nguyen, TY Vu, TC Dakal, B Dhabhai… - PloS one, 2021 - journals.plos.org
In the present study, in silico predictions and molecular docking were performed on five
clerodane diterpenes (1–5) from Polyalthia longifolia seeds to evaluate their potential as …