Ca2+ is a ubiquitous cellular signal. Altered expression of specific Ca2+ channels and
pumps are characterizing features of some cancers. The ability of Ca2+ to regulate both cell …

Epilepsy is considered one of the most common neurological disorders worldwide. Oxidative
stress produced by free radicals may play a role in the initiation and progression of epilepsy; …

Although it is widely accepted that mitochondria in living cells can efficiently uptake Ca 2+
during stimulation because of their vicinity to microdomains of high [Ca 2+], the direct proof …

ER stress–induced apoptosis is implicated in various pathological conditions, but the
mechanisms linking ER stress–mediated signaling to downstream apoptotic pathways …

Bisphenol A (BPA) is widely distributed in the environment and human surroundings and is
closely related to the occurrence of many chronic diseases including female infertility …

Nearly all resident proteins of the organelles along the secretory pathway, as well as
proteins that are expressed at the cell surface or secreted from the cell, are first co …

Cellular stress elicited by the toxic metal Cd 2+ does not coerce the cell into committing to
die from the onset. Rather, detoxification and adaptive processes are triggered concurrently …

By transiently or stably overexpressing the mitochondrial fission factor dynamin-related
protein-1 (Drp-1), we evaluated the role of mitochondrial division in organelle Ca 2+ …

Rhabdomyolysis is defined as a pathological condition of skeletal muscle cell damage
leading to the release of toxic intracellular material into the blood circulation. Its major …

Virulent Mycobacterium tuberculosis (Mtb) induces a maladaptive cytolytic death modality,
necrosis, which is advantageous for the pathogen. We report that necrosis of macrophages …