The ER is one of the most important folding compartments within the cell, as well as an
intracellular Ca^(2+) storage organelle and it contains a number of Ca^(2+) regulated …

Mitochondria from every tissue are quite similar in their capability to accumulate Ca 2+ in a
process that depends on the electrical potential across the inner membrane; it is catalyzed …

The store-operated calcium channels (SOCs) represent one of the major calcium-entry
pathways in non-excitable cells. SOCs and in particular their major components ORAI1 and …

Simple Summary The development of new methods of anticancer therapy is an urgent task
of modern biology. The use of selenium and its compounds as anticancer drugs have …

Programmed cell death is vital for a number of pathophysiologic settings. Apoptotic cells are
rapidly engulfed by phagocytes (ie, macrophages), which in turn acquire an anti …

Depression is a neuropsychiatric disease that threatens the physical and mental health of
humans worldwide. This study explored the potential anti-depressant effects of ginsenoside …

In previous studies, we confirmed that mitofusin-2 (Mfn2) induced apoptosis in
hepatocellular carcinoma (HCC) cells. However, the exact molecular mechanism remained …

Regulation of apoptosis is tightly linked with the targeting of numerous Bcl-2 proteins to the
mitochondrial outer membrane (MOM), where their activation or inhibition dictates cell death …

Medium optimization is a crucial step during cell culture for biopharmaceutics and
regenerative medicine; however, this step remains challenging, as both media and cells are …

Ammonia is one of the most important toxic metabolites in the intestine of animals. It can
cause intestinal damage and associated intestinal diseases through different endogenous …