Globally, colorectal cancer (CRC) is the third most commonly diagnosed malignancy and the
second leading cause of cancer death. Arising through three major pathways, including …

Introduction Advances in our understanding of the molecular genetics and epigenetics of
colorectal cancer have led to novel insights into the pathogenesis of this common cancer …

Objective Sessile serrated adenomas (SSAs) are the precursors of at least 15% of colorectal
carcinomas, but their biology is incompletely understood. We performed a …

Colorectal cancer (CRC) is considered a heterogeneous disease, both regarding
pathogenesis and clinical behaviour. Four decades ago, the adenoma–carcinoma pathway …

Background & Aims Genetic and epigenetic alterations contribute to the pathogenesis of
colorectal cancer (CRC). There is considerable molecular heterogeneity among colorectal …

The prevalence of invasive Fusobacterium nucleatum (Fn) within the serrated neoplasia
pathway of the proximal colon has seldom been investigated. We examined the invasive Fn …

Approximately 30% of colorectal carcinomas develop via the serrated neoplasia pathway
characterized by widespread DNA methylation and frequent BRAF mutation. Serrated …

Serrated adenocarcinoma is a recently described subset of colorectal cancer (CRC), which
account for about 10% of all CRCs and follows an alternative pathway in which serrated …

Recent studies have mapped key genetic changes in colorectal cancer (CRC) that impact
important pathways contributing to the multistep models for CRC initiation and development …

Sessile serrated adenomas are the precursor polyp of approximately 20% of colorectal
carcinomas. Sessile serrated adenomas with dysplasia are rarely encountered and …