Background: Serotonin-noradrenaline reuptake inhibitors (SNRI) are widely used in medical
practice. Their discontinuation has been associated with a wide range of symptoms. The aim …

Background Fibromyalgia is a clinically defined chronic condition of unknown etiology
characterized by chronic widespread pain that often co‐exists with sleep disturbances …

Importance Amitriptyline is an established medication used off-label for the treatment of
fibromyalgia, but pregabalin, duloxetine, and milnacipran are the only pharmacological …

BACKGROUND: Recent neurophysiological evidence attests to the validity of fibromyalgia
(FM), a chronic pain condition that affects> 2% of the population. OBJECTIVES: To present …

Although there is no known cure for fibromyalgia, multidisciplinary team efforts using
combined treatment approaches, including patient education, aerobic exercise, cognitive …

Background Chronic pain is common in adults, and often has a detrimental impact upon
physical ability, well‐being, and quality of life. Previous reviews have shown that certain …

Introduction: Fibromyalgia is a syndrome characterized by chronic generalized pain in
addition to different symptoms such as fatigue, sleep disturbances, stiffness, cognitive …

Duloxetine is a serotonin-norepinephrine reuptake inhibitor approved for the treatment of
patients affected by major depressive disorder (MDD), generalized anxiety disorder (GAD) …

Background Pain is a common feature of childhood and adolescence around the world, and
for many young people, that pain is chronic. The World Health Organization guidelines for …

Background: Duloxetine is a selective dual neuronal serotonin (5‐Hydroxytryptamine, 5‐HT)
and norepinephrine reuptake inhibitor (SSNRI). It is indicated in the United States for …