Obesity has been linked to the increased risk and aggressiveness of many types of
carcinoma. A state of chronic inflammation in adipose tissue (AT), resulting in genotoxic …

Apelin is an endogenous peptide identified as a ligand of the G protein-coupled receptor
APJ. Apelin belongs to the family of adipokines, which are bioactive mediators released by …

Excess body weight is associated not only with an increased risk of type 2 diabetes and
cardiovascular disease (CVD) but also with various types of malignancies. Adiponectin, the …

Adiponectin is a fat-derived hormone whose reduction plays central roles in obesity-linked
diseases including insulin resistance/type 2 diabetes and atherosclerosis. The cloning of …

Epidemiological studies suggest a positive association between obesity and type 2 diabetes
mellitus (T2D) with the risk of cancer and cancer-related mortality. Insulin resistance …

Diabetes is associated with an increased risk of developing and dying from cancer. This
increased risk may be due to hyperglycemia, hyperinsulinemia, and insulin resistance or …

Adipose-tissue-derived signaling molecules, including the adipokines, are emerging as key
candidate molecules that link obesity with cancer. Peritumoral, stromal, adipose tissue and …

The incidence of obesity in US adults has been steadily increasing over the past few
decades. Many comorbidities associated with obesity have been well-established such as …

Significant correlations between obesity and incidence of various cancers have been
reported. Obesity, considered a mild inflammatory process, is characterized by a high level …

Obesity is increasing worldwide and reaches to a large proportion of the population in
developed countries. Thus, obesity‐associated cancer has become a major health problem …