Objectives Recent evidence suggests that hyperinsulinemia associated with obesity may be
a significant risk factor for the development of endometrial cancer. Metformin is used in type …

Obesity has been associated with increased incidence and risk of mortality of prostate
cancer. One of the proposed mechanisms underlying this risk association is the change in …

Ellagic acid (EA) has been proposed as a promising candidate for therapeutic use in colon
cancer. Investigation of the effectiveness of EA in a leptin-enriched model might have been …

Background Type-II endometrial cancer is an estrogen independent and one of the most
lethal types of cancer having poor prognosis. Adipokines play a crucial role in the triggering …

Epidemiological evidence points to a link between insulin resistance (IR) and breast cancer
(BrCA). Insulin plays a role in CD8+ T cells (CD8T) differentiation and function and affects …

Diabetes is a serious metabolic disease that causes multiple organ dysfunctions. Recent
evidence suggests that diabetes could contribute to the initiation and progression of certain …

Aims Metformin is a clinical drug administered to patients to treat type 2 diabetes mellitus
that was found to be associated with a lower risk of occurrence of cancer and cancer-related …

[Frontiers in Bioscience 17, 2550-2558, June 1, 2012] 2550 Association between obesity and
gallbladder cancer Fei Wang1, Bingyua Page 1 [Frontiers in Bioscience 17, 2550-2558, June …

Obesity may create a mitogenic microenvironment that influences tumor initiation and
progression. The obesity-associated adipokine, leptin regulates energy metabolism and has …

Obesity has long been recognized as a risk factor for diabetes and cardiovascular disease.
Recent epidemiological data also associate obesity with cancer risk and progression. For …