The HIV-1 capsid, a conical shell encasing viral nucleoprotein complexes, is involved in
multiple post-entry processes during viral replication. Many host factors can directly bind to …

Intracellular innate immunity involves co-evolved antiviral restriction factors that specifically
inhibit infecting viruses. Studying these restrictions has increased our understanding of viral …

There are limited data describing the functional characteristics of HIV-1 specific antibodies in
breast milk (BM) and their role in breastfeeding transmission. The ability of BM antibodies to …

Interferon-induced transmembrane proteins (IFITMs) restrict the entry of diverse enveloped
viruses through incompletely understood mechanisms. While IFITMs are reported to inhibit …

Human immunodeficiency virus (HIV) and other lentiviruses adapt to new hosts by evolving
to evade host-specific innate immune proteins that differ in sequence and often viral …

Identifying naturally-occurring neutralizing antibodies (NAb) that are cross-reactive against
all global subtypes of HIV-1 is an important step toward the development of a vaccine …

ABSTRACT HIV-1 replicates poorly in macaque cells, and this had hindered the
advancement of relevant nonhuman primate model systems for HIV-1 infection and …

Like all viruses, human immunodeficiency viruses (HIVs) and their primate lentivirus
relatives must enter cells in order to replicate and, once produced, new virions need to exit …

The relevance of simian/human immunodeficiency virus (SHIV) infection of macaques to HIV-
1 infection in humans depends on how closely SHIVs mimic HIV-1 transmission …

Host antiviral proteins inhibit primate lentiviruses and other retroviruses by targeting many
features of the viral life cycle. The lentiviral capsid protein and the assembled viral core are …