[HTML][HTML] Gut–brain axis as a pathological and therapeutic target for neurodegenerative disorders

ARL Toledo, GR Monroy, FE Salazar, JY Lee… - International journal of …, 2022 - mdpi.com
Human lifestyle and dietary behaviors contribute to disease onset and progression.
Neurodegenerative diseases (NDDs), considered multifactorial disorders, have been …

[HTML][HTML] Brain washing and neural health: role of age, sleep, and the cerebrospinal fluid melatonin rhythm

RJ Reiter, R Sharma, MS Cucielo, DX Tan… - Cellular and Molecular …, 2023 - Springer
The brain lacks a classic lymphatic drainage system. How it is cleansed of damaged
proteins, cellular debris, and molecular by-products has remained a mystery for decades …

Glymphatic system impairment in Alzheimer's disease: associations with perivascular space volume and cognitive function

X Zhang, Y Wang, B Jiao, Z Wang, J Shi, Y Zhang… - European …, 2024 - Springer
Objectives To investigate glymphatic function in Alzheimer's disease (AD) using the diffusion
tensor image analysis along the perivascular space (DTI-ALPS) method and to explore the …

Regional glymphatic abnormality in behavioral variant frontotemporal dementia

D Jiang, L Liu, Y Kong, Z Chen… - Annals of …, 2023 - Wiley Online Library
Objectives Glymphatic function has not yet been explored in behavioral variant
frontotemporal dementia (bvFTD). The spatial correlation between regional glymphatic …

[HTML][HTML] Metabolic contribution and cerebral blood flow regulation by astrocytes in the neurovascular unit

S Takahashi - Cells, 2022 - mdpi.com
The neurovascular unit (NVU) is a conceptual framework that has been proposed to better
explain the relationships between the neural cells and blood vessels in the human brain …

[HTML][HTML] Perivascular spaces, glymphatic system and MR

L Yu, X Hu, H Li, Y Zhao - Frontiers in Neurology, 2022 - frontiersin.org
The importance of the perivascular space (PVS) as one of the imaging markers of cerebral
small vessel disease (CSVD) has been widely appreciated by the neuroradiologists. The …

Noninvasive magnetic resonance imaging measures of glymphatic system activity

K Kamagata, Y Saito, C Andica… - Journal of Magnetic …, 2024 - Wiley Online Library
The comprehension of the glymphatic system, a postulated mechanism responsible for the
removal of interstitial solutes within the central nervous system (CNS), has witnessed …

Evaluation of glymphatic system activity by diffusion tensor image analysis along the perivascular space (DTI-ALPS) in dementia patients

T Liang, F Chang, Z Huang, D Peng… - The British journal of …, 2023 - academic.oup.com
Objectives: Dementia is a clinical syndrome caused by multiple etiologies, usually manifests
with progressive and diffuse brain dysfunction. The activity of the human glymphatic system …

[HTML][HTML] Novel developments in non-contrast enhanced MRI of the perivascular clearance system: What are the possibilities for Alzheimer's disease research?

MM van der Thiel, WH Backes, IHGB Ramakers… - Neuroscience & …, 2023 - Elsevier
The cerebral waste clearance system (ie, glymphatic or intramural periarterial drainage)
works through a network of perivascular spaces (PVS). Dysfunction of this system likely …

Imaging interstitial fluid with MRI: a narrative review on the associations of altered interstitial fluid with vascular and neurodegenerative abnormalities

GS Drenthen, EP Elschot… - Journal of Magnetic …, 2024 - Wiley Online Library
Interstitial fluid (ISF) refers to the fluid between the parenchymal cells and along the
perivascular spaces (PVS). ISF plays a crucial role in delivering nutrients and clearing waste …