Recent advances in contrast-enhanced photoacoustic imaging: overcoming the physical and practical challenges

W Choi, B Park, S Choi, D Oh, J Kim, C Kim - Chemical Reviews, 2023 - ACS Publications
For decades now, photoacoustic imaging (PAI) has been investigated to realize its potential
as a niche biomedical imaging modality. Despite its highly desirable optical contrast and …

Strategic design of conquering hypoxia in tumor for advanced photodynamic therapy

C Zhang, X Hu, L Jin, L Lin, H Lin… - Advanced Healthcare …, 2023 - Wiley Online Library
Photodynamic therapy (PDT), with its advantages of high targeting, minimally invasive, and
low toxicity side effects, has been widely used in the clinical therapy of various tumors …

Metabolic reprogramming mediated PD-L1 depression and hypoxia reversion to reactivate tumor therapy

Z Zhou, Y Liu, W Song, X Jiang, Z Deng… - Journal of Controlled …, 2022 - Elsevier
As a promising cancer treatment, photodynamic therapy (PDT) still achieved limited clinical
success due to the severe hypoxia and programmed death ligand-1 (PD-L1) over-expressed …

Dual‐Responsive Nanocomposites for Synergistic Antibacterial Therapies Facilitating Bacteria‐Infected Wound Healing

S Cheng, M Qi, W Li, W Sun, M Li, J Lin… - Advanced …, 2023 - Wiley Online Library
The rising dangers of bacterial infections have created an urgent need for the development
of a new generation of antibacterial technologies and therapeutics. Antibacterial …

Photoactivatable immunostimulatory nanomedicine for immunometabolic cancer therapy

W Wu, Y Pu, B Zhou, Y Shen, S Gao… - Journal of the …, 2022 - ACS Publications
A rationally designed immunostimulant (CC@ SiO2-PLG) with a photoactivatable
immunotherapeutic function for synergetic tumor therapy is reported. This CC@ SiO2-PLG …

Biocatalytic depletion of tumorigenic energy sources driven by cascade reactions for efficient antitumor therapy

YP Xiao, PH Chen, S Lei, F Bai, LH Fu… - Angewandte Chemie …, 2022 - Wiley Online Library
Glucose and lactate play important roles for tumor growth. How to simultaneously deprive
tumors of glucose and lactate is a big challenge. We have developed a cascade catalytic …

Killing three birds with one stone: Multi-stage metabolic regulation mediated by clinically usable berberine liposome to overcome photodynamic immunotherapy …

C Zheng, W Luo, Y Liu, J Chen, H Deng, Z Zhou… - Chemical Engineering …, 2023 - Elsevier
Nowadays, photodynamic therapy (PDT) has become a novel effect modality for cancer
therapy. But, facing the extremely hypoxic tumor microenvironment, the efficacy of PDT is still …

Heptamethine Cyanine‐Based Nanotheranostics with Catalase‐Like Activity for Synergistic Phototherapy of Cancer

M Liang, X Mu, Y Li, Y Tan, X Hao… - Advanced Functional …, 2023 - Wiley Online Library
Single‐molecule photosensitizers (PSs) for synergistic phototherapy are desirable but highly
challenging, due to the competitive relationship between photothermal (PTT) and …

Nanoparticles mediated tumor microenvironment modulation: current advances and applications

GSR Raju, E Pavitra, GL Varaprasad… - Journal of …, 2022 - Springer
The tumor microenvironment (TME) plays a key role in cancer development and emergence
of drug resistance. TME modulation has recently garnered attention as a potential approach …

Recent advances in strategies for addressing hypoxia in tumor photodynamic therapy

L Hong, J Li, Y Luo, T Guo, C Zhang, S Ou, Y Long… - Biomolecules, 2022 - mdpi.com
Photodynamic therapy (PDT) is a treatment modality that uses light to target tumors and
minimize damage to normal tissues. It offers advantages including high spatiotemporal …