The original formulation of Gate Control Theory (GCT) proposed that the perception of pain
produced by spinal cord signaling to the brain depends on a balance of activity generated in …

Itch is a topic to which everyone can relate. The physiological roles of itch are increasingly
understood and appreciated. The pathophysiological consequences of itch impact quality of …

Paralleling the activation of dorsal horn microglia after peripheral nerve injury is a significant
expansion and proliferation of macrophages around injured sensory neurons in dorsal root …

Persistent mechanical hypersensitivity that occurs in the setting of injury or disease remains
a major clinical problem largely because the underlying neural circuitry is still not known …

Although itch sensation is an important protective mechanism for animals, chronic itch
remains a challenging clinical problem. Itch processing has been studied extensively at the …

Itch is described as an irritating sensation that triggers a desire to scratch. However, this
definition hardly seems fitting for the millions of people who suffer from intractable itch …

Reflecting a decade's worth of changes, Human Safety and Risk Management, Second
Edition contains new chapters addressing safety culture and models of risk as well as an …

Itch is one of the most primal sensations, being both ubiquitous and important for the well-
being of animals. For more than a century, a desire to understand how itch is encoded by the …

Although microglia have been implicated in nerve injury–induced neuropathic pain, the
manner by which injured sensory neurons engage microglia remains unclear. We found that …

Pain information processing in the spinal cord has been postulated to rely on nociceptive
transmission (T) neurons receiving inputs from nociceptors and Aβ mechanoreceptors, with …