Kidney fibrosis, characterized by excessive deposition of extracellular matrix (ECM) that
leads to tissue scarring, is the final common outcome of a wide variety of chronic kidney …

The last decade has been somewhat of a renaissance period for the field of macrophage
biology. This renewed interest, combined with the advent of new technologies and …

Summary COVID-19-induced" acute respiratory distress syndrome"(ARDS) is associated
with prolonged respiratory failure and high mortality, but the mechanistic basis of lung injury …

Purpose The lack of effective molecular biomarkers to monitor idiopathic pulmonary fibrosis
(IPF) activity or treatment response remains an unmet clinical need. Herein, we determined …

Tissue injury can drive secondary organ injury; however, mechanisms and mediators are not
well understood. To identify interorgan cross-talk mediators, we used acute kidney injury …

In the presence of tissue inflammation, injury, or cancer, myeloid cells are recruited to
disease regions through a multi-step process involving myelopoiesis, chemotaxis, cell …

The lack of techniques for noninvasive imaging of inflammation has challenged precision
medicine management of acute respiratory distress syndrome (ARDS). Here, we determined …

Giant cell arteritis (GCA) and polymyalgia rheumatica (PMR) are two interrelated
inflammatory diseases affecting patients above 50 years of age. Patients with GCA suffer …

Among the diverse populations of myeloid cells that reside within the healthy and diseased
heart, CC chemokine receptor type 2 (CCR2) is specifically expressed on inflammatory …

Idiopathic pulmonary fibrosis (IPF), characterized by progressive worsening of dyspnea and
irreversible decline in lung function, is a chronic and progressive respiratory disease with a …