Evolution, global spread, and pathogenicity of highly pathogenic avian influenza H5Nx clade 2.3. 4.4

DH Lee, K Bertran, JH Kwon… - Journal of veterinary …, 2017 - synapse.koreamed.org
Novel subtypes of Asian-origin (Goose/Guangdong lineage) H5 highly pathogenic avian
influenza (HPAI) viruses belonging to clade 2.3. 4, such as H5N2, H5N5, H5N6, and H5N8 …

Global review of the H5N8 avian influenza virus subtype

S Rafique, F Rashid, S Mushtaq, A Ali, M Li… - Frontiers in …, 2023 - frontiersin.org
Orthomyxoviruses are negative-sense, RNA viruses with segmented genomes that are
highly unstable due to reassortment. The highly pathogenic avian influenza (HPAI) subtype …

Infectivity, transmission and pathogenicity of H5 highly pathogenic avian influenza clade 2.3. 4.4 (H5N8 and H5N2) United States index viruses in Pekin ducks and …

MJ Pantin-Jackwood, M Costa-Hurtado, K Bertran… - Veterinary …, 2017 - Springer
In late 2014, a H5N8 highly pathogenic avian influenza (HPAI) virus, clade 2.3. 4.4, spread
by migratory waterfowl into North America reassorting with low pathogenicity AI viruses to …

A novel European H5N8 influenza A virus has increased virulence in ducks but low zoonotic potential

C Grund, D Hoffmann, R Ulrich, M Naguib… - Emerging microbes & …, 2018 - Taylor & Francis
We investigated in a unique setup of animal models and a human lung explant culture
biological properties, including zoonotic potential, of a representative 2016 highly …

Widespread detection of highly pathogenic H5 influenza viruses in wild birds from the Pacific Flyway of the United States

SN Bevins, RJ Dusek, CL White, T Gidlewski… - Scientific reports, 2016 - nature.com
A novel highly pathogenic avian influenza virus belonging to the H5 clade 2.3. 4.4 variant
viruses was detected in North America in late 2014. Motivated by the identification of these …

Characterization of highly pathogenic avian influenza H5N8 virus from Egyptian domestic waterfowl in 2017

A Anis, M AboElkhair, M Ibrahim - Avian pathology, 2018 - Taylor & Francis
In 2016, the highly pathogenic avian influenza (HPAI) H5N8 virus was detected in wild birds
for the first time in Egypt. In the present study, we identified the HPAI virus H5N8 of clade 2.3 …

T160A mutation-induced deglycosylation at site 158 in hemagglutinin is a critical determinant of the dual receptor binding properties of clade 2.3. 4.4 H5NX subtype …

R Gao, M Gu, K Liu, Q Li, J Li, L Shi, X Li, X Wang… - Veterinary …, 2018 - Elsevier
Abstract Most clade 2.3. 4.4 H5NX subtype avian influenza viruses possess a T160A amino
acid substitution in the hemagglutinin (HA) protein that has been shown to affect the receptor …

Pathogenicity of H5N8 avian influenza virus in chickens and in duck breeds and the role of MX1 and IFN-α in infection outcome and transmission to contact birds

A Nahed, WSH Abd El Naby, EGS Hussein… - … and Infectious Diseases, 2023 - Elsevier
This study examined the pathogenicity, immunogenicity, and transmission potential of the
H5N8 HPAI clade 2.3. 4.4 b virus in three breeds of ducks and in broiler chickens. Chickens …

Genetic analysis and biological characteristics of different internal gene origin H5N6 reassortment avian influenza virus in China in 2016

W Sun, J Li, J Hu, D Jiang, C Xing, T Zhan, X Liu - Veterinary microbiology, 2018 - Elsevier
Abstract Clade 2.3. 4.4 of H5N6 subtype Avian Influenza Viruses (AIVs) has become
dominant clade in South-East Asia. So far, a total of 16 cases of human infection, including 6 …

Continued reassortment of avian H6 influenza viruses from Southern China, 2014–2016

J Li, C Quan, Y Xie, C Ke, Y Nie, Q Chen… - Transboundary and …, 2019 - Wiley Online Library
H6 subtype avian influenza virus (AIV) was prevalent in poultry and could sporadically infect
humans. Here, a total of 196 novel H6 AIV s isolated from poultry in eight provinces of China …