Depression and anxiety in inflammatory bowel disease: epidemiology, mechanisms and treatment

TH Bisgaard, KH Allin, L Keefer… - Nature reviews …, 2022 - nature.com
Inflammatory bowel disease (IBD), which includes Crohn's disease and ulcerative colitis, is a
chronic, relapsing immune-mediated disease with a varying and sometimes severe disease …

Stress and the brain-gut axis in functional and chronic-inflammatory gastrointestinal diseases: A transdisciplinary challenge

A Labanski, J Langhorst, H Engler… - …, 2020 - Elsevier
The broad role of stress in the brain-gut axis is widely acknowledged, with implications for
multiple prevalent health conditions that are characterized by chronic gastrointestinal …

[HTML][HTML] Inflammatory bowel diseases, interleukin-6 and interleukin-6 receptor subunit alpha in causal association with cerebral cortical structure: a Mendelian …

C Liu, S Zhu, J Zhang, K Ren, K Li, J Yu - Frontiers in Immunology, 2023 - frontiersin.org
Background Neurological involvement and psychiatric manifestations have been
documented in clinical cases of inflammatory bowel disease (IBD); however, the presence of …

Exploring joint patterns of brain structure and function in inflammatory bowel diseases using multimodal data fusion

AK Thomann, MM Schmitgen, D Kmuche… - …, 2021 - Wiley Online Library
Background A growing number of neuroimaging studies suggest distinct neural changes in
inflammatory bowel diseases (IBDs). Whether such changes may show similar spatial …

Brain functional changes in patients with Crohn's disease: A resting‐state fMRI study

L Li, J Ma, JG Xu, YL Zheng, Q Xie, L Rong… - Brain and …, 2021 - Wiley Online Library
Background Crohn's disease (CD) is a chronic recurrent intestinal inflammatory disease,
often accompanied by poor adaptation and excessive stress response. However, the …

Persistent central inflammation and region specific cellular activation accompany depression-and anxiety-like behaviours during the resolution phase of experimental …

E Dempsey, A Abautret-Daly, NG Docherty… - Brain, behavior, and …, 2019 - Elsevier
Depression and anxiety-related psychological symptoms are increasingly recognised as
important co-morbidities in patients with inflammatory bowel disease (IBD). Dextran sulfate …

Differential brain structural and functional patterns in Crohn's disease patients are associated with different disease stages

A Agostini, F Benuzzi, D Ballotta… - Inflammatory Bowel …, 2023 - academic.oup.com
Background Crohn's disease (CD) is an inflammatory, chronic disorder that alternates
between a quiescent phase and inflammatory flare-ups. Research has begun to elucidate …

Brain resting-state network alterations associated with Crohn's disease

J Kornelsen, A Wilson, JS Labus, K Witges… - Frontiers in …, 2020 - frontiersin.org
Inflammatory bowel disease (IBD) is a chronic disease that is associated with aspects of
brain anatomy and activity. In this preliminary MRI study, we investigated differences in brain …

RORγt-Expressing pathogenic CD4+ T cells cause brain inflammation during chronic colitis

ME Mickael, S Bhaumik, A Chakraborti… - The Journal of …, 2022 - journals.aai.org
Neurobehavioral disorders and brain abnormalities have been extensively reported in both
Crohn's disease and ulcerative colitis patients. However, the mechanism causing …

Cognitive impairment in adult inflammatory bowel disease: a systematic review and meta-analysis

CWP Hopkins, N Powell, C Norton, JL Dumbrill… - Journal of the Academy …, 2021 - Elsevier
Background People living with inflammatory bowel disease (IBD) are exposed to multiple
risk factors for cognitive impairment and frequently report cognitive difficulties. However, the …