Omics techniques generate large, multidimensional data that are amenable to analysis by
new informatics approaches alongside conventional statistical methods. Systems theories …

Systemic vascular inflammation plays multiple maladaptive roles which contribute to the
progression and destabilization of atherosclerotic cardiovascular disease (ASCVD). These …

Implementing precision medicine hinges on the integration of omics data, such as
proteomics, into the clinical decision-making process, but the quantity and diversity of …

Complex diseases, such as coronary artery disease (CAD), are often multifactorial, caused
by multiple underlying pathological mechanisms. Here, to study the multifactorial nature of …

Environmental factors are the largest contributors to cardiovascular disease. Here we show
that cardiac organoids that incorporate an oxygen-diffusion gradient and that are stimulated …

Cellular senescence is a state of irreversible cell cycle arrest associated with ageing.
Senescence of different cardiac cell types can direct the pathophysiology of cardiovascular …

Life expectancy has increased by three decades since the mid-twentieth century. Parallel
healthspan expansion has however not followed, largely impeded by the pandemic of …

Cardiac imaging plays an important role in the diagnosis of cardiovascular disease (CVD).
Until now, its role has been limited to visual and quantitative assessment of cardiac structure …

Cardiotoxicity is one of the most serious side effects of cancer chemotherapy. Current
approaches to monitoring of chemotherapy‐induced cardiotoxicity (CIC) as well as model …

Rationale: Accumulating evidence implicates inflammation in pulmonary arterial
hypertension (PAH) and therapies targeting immunity are under investigation, although it …