Epithelial cells require apical–basal plasma membrane polarity to carry out crucial vectorial
transport functions and cytoplasmic polarity to generate different cell progenies for tissue …

Live-cell imaging reveals the endolysosomal system as a complex and highly dynamic
network of interacting compartments. Distinct types of endosomes are discerned by kinetic …

Actin cytoskeleton dynamics play vital roles in most forms of intracellular trafficking by
promoting the biogenesis and transport of vesicular cargoes. Mounting evidence indicates …

Members of the Rab or ARF/Sar branches of the Ras GTPase superfamily regulate almost
every step of intracellular membrane traffic. A rapidly growing body of evidence indicates …

The mitochondrial network constantly changes and remodels its shape to face the cellular
energy demand. In human cells, mitochondrial fusion is regulated by the large, evolutionarily …

Stimulated emission depletion (STED) nanoscopy allows observations of subcellular
dynamics at the nanoscale. Applications have, however, been severely limited by the lack of …

In eukaryotic cells, protein sorting is a highly regulated mechanism important for many
physiological events. After synthesis in the endoplasmic reticulum and trafficking to the Golgi …

Macrophages have the capacity to rapidly secrete a wide range of inflammatory mediators
that influence the development and extent of an inflammatory response. Newly synthesized …

Abscission is the least understood step of cytokinesis. It consists of the final cut of the
intercellular bridge connecting the sister cells at the end of mitosis, and is thought to involve …

Podosomes are adhesion structures formed in monocyte-derived cells. They are F-actin-rich
columns perpendicular to the substrate surrounded by a ring of integrins. Here, to measure …