The Potential Use of Peptides in the Fight against Chagas Disease and Leishmaniasis

N Qvit, M Zerihun, M Kumar, H Berhe - 2023 - preprints.org
Parasitic diseases are among the most serious public health problems in developing
countries, causing high mortality and economic burdens. The Trypanosomatidae family …

[PDF][PDF] Consequential drug combinations for tuberculosis treatments

CJ Pyle, DM Tobin - Cell Systems, 2021 - cell.com
Improved therapies for tuberculosis will require the careful revision of complex, multi-drug
regimens. In this issue of Cell Systems, Larkins-Ford et al. integrate extensive dose …

[图书][B] PKPD-Model Based Preclinical Characterization of the Activity of Spectinamide 1599 Against Mycobacterial Subpopulations and the Identification of Potential …

ZH Temrikar - 2023 - search.proquest.com
Tuberculosis is one of the top 10 causes of death worldwide and the leading cause of death
from a single infectious agent prior to COVID19. Mycobacterium tuberculosis (Mtb) is the …

Transcriptome signature of cell viability predicts drug response and drug interaction for Tuberculosis

V Srinivas, RA Ruiz, M Pan, SR Christinal Immanuel… - bioRxiv, 2021 - biorxiv.org
The treatment of tuberculosis (TB), which kills 1.8 million each year, remains difficult,
especially with the emergence of multidrug resistant strains of Mycobacterium tuberculosis …

In vitro Methods to Better Evaluate Drug Responses in Cancer

H Schwartz - 2022 - repository.escholarship.umassmed …
Evaluating anti-cancer drugs in vitro is an important aspect of the drug development
pipeline. When evaluating anti-cancer drugs, two different measurements are used: relative …

RNA-based vaccine demonstrates prophylactic efficacy against Mycobacterium tuberculosis challenge in a mouse model

SE Larsen, JH Erasmus, VA Reese, T Pecor, J Archer… - bioRxiv, 2022 - biorxiv.org
Mycobacterium tuberculosis (Mtb) is an opportunistic bacterial pathogen that causes
tuberculosis disease (TB) and exerts an extensive burden on global health. The complex …

[图书][B] Chemical Biology and Genetic Studies Targeting the Mycobacterial Cell Envelope

JT Williams - 2021 - search.proquest.com
Mycobacterium tuberculosis is one of the leading causes of death due to a single infectious
pathogen. The evolution and spread of drug resistant strains requires new antibiotics to …

[PDF][PDF] A continuous epistasis model for predicting growth rate given combinatorial variation in gene expression and environment

KA Reynolds - scholar.archive.org
The ability to predict changes in cellular growth rate given variation in gene expression is
critical to interpret disease-causing mutations, engineer biosynthetic pathways, and …

Hydrolysis or Cyclization of ATP: Regulating Cholesterol Utilization in Mycobacterium tuberculosis

KM Wilburn - 2021 - search.proquest.com
Tuberculosis remains a major cause of human morbidity and mortality, and is caused by
infection with the bacterium Mycobacterium tuberculosis. For thousands of years, M …