Human epidermal growth factor receptor 2 (HER2) is involved in the pathogenesis and poor
outcomes of several types of cancer, including advanced gastric and gastroesophageal …

Numerous epidemiological and pre-clinical studies have demonstrated that the
insulin/insulin-like growth factor (IGF) system plays a key role in the development and …

Purpose The human epidermal growth factor receptor (HER) family consists of four
members: ErbB-1 (HER1), ErbB-2 (HER2), ErbB-3 (HER3), and ErbB-4 (HER4). These …

Gastric cancer is the third leading cause of cancer mortality worldwide. As surgery is the only
curative treatment strategy and conventional chemotherapy has shown limited efficacy-with …

With the availability of a therapeutic target and an effective agent in trastuzumab, a
systematic examination of the literature to investigate the role of human epidermal growth …

Background Some tyrosine kinase receptors (RTKs) play critical roles in gastric cancer
progression. Not only trastuzumab, but also several other agents targeting RTKs are being …

Background There are two distinct types of gastric carcinoma (GC), intestinal, more
frequently sporadic and linked to environmental factors, and diffuse (undifferentiated) that is …

BACKGROUND & AIMS: Lymphoepithelioma-like carcinoma (LELC) is a rare subtype of
gastric carcinoma (GC) with a better survival rate than other GCs; most cases of LELC are …

The pathogenesis of gastric cancer is complex and related to multiple factors. Dysregulation
of intracellular signaling pathways represents a common pathogenic mechanism and may …

Background This study was conducted to investigate whether human epidermal growth
factor receptor 2 (HER2) status, epidermal growth factor receptor (EGFR) status, and c-MET …