Major Depressive Disorder (MDD) is a leading cause of disability worldwide, creating a high
medical and socioeconomic burden. There is a growing interest in the biological …

Crosstalk between inflammatory pathways and neurocircuits in the brain can lead to
behavioural responses, such as avoidance and alarm, that are likely to have provided early …

Posttraumatic stress disorder (PTSD) develops in a subset of individuals upon exposure to
traumatic stress. In addition to well-defined psychological and behavioral symptoms, some …

Despite decades of intensive research, the biological mechanisms that causally underlie
depression are still unclear, and therefore the development of novel effective antidepressant …

Background: Studies investigating the impact of a variety of inflammatory stimuli on the brain
and behavior have reported evidence that inflammation and release of inflammatory …

Depression's burden of disease goes beyond functioning and quality of life and extends to
somatic health. Results from longitudinal cohort studies converge in illustrating that major …

Tryptophan (TRP), an essential amino acid in mammals, is involved in several physiological
processes including neuronal function, immunity, and gut homeostasis. In humans, TRP is …

Cytokines have been implicated in the pathology of depression. Currently, the evidence is
based on cross-sectional studies and meta-analytic research comparing blood …

Mounting evidence indicates that inflammatory cytokines contribute to the development of
depression in both medically ill and medically healthy individuals. Cytokines are important …

Depression is the most common psychiatric disorder worldwide. The burden of disease for
depression goes beyond functioning and quality of life and extends to somatic health …