Multilevel omics for the discovery of biomarkers and therapeutic targets for stroke

J Montaner, L Ramiro, A Simats, S Tiedt… - Nature Reviews …, 2020 - nature.com
Despite many years of research, no biomarkers for stroke are available to use in clinical
practice. Progress in high-throughput technologies has provided new opportunities to …

The role of selected pro-inflammatory cytokines in pathogenesis of ischemic stroke

H Pawluk, A Woźniak, G Grześk… - … interventions in aging, 2020 - Taylor & Francis
Stroke is currently one of the most common causes of death and disability in the world, and
its pathophysiology is a complex process, involving the oxidative stress and inflammatory …

[HTML][HTML] Systemic inflammatory response index and futile recanalization in patients with ischemic stroke undergoing endovascular treatment

S Lattanzi, D Norata, AA Divani, M Di Napoli, S Broggi… - Brain Sciences, 2021 - mdpi.com
Futile recanalization remains a significant challenge for endovascular treatment (EVT) of
acute ischemic stroke (AIS). The inflammatory response that occurs after cerebral infarct …

[HTML][HTML] Acute stroke biomarkers: are we there yet?

M Dagonnier, GA Donnan, SM Davis… - Frontiers in …, 2021 - frontiersin.org
Background: Distinguishing between stroke subtypes and knowing the time of stroke onset
are critical in clinical practice. Thrombolysis and thrombectomy are very effective treatments …

Blood biomarkers for stroke diagnosis and management

J Kamtchum-Tatuene, GC Jickling - Neuromolecular medicine, 2019 - Springer
Biomarkers are objective indicators used to assess normal or pathological processes,
evaluate responses to treatment and predict outcomes. Many blood biomarkers already …

Blood biomarkers in ischemic stroke: potential role and challenges in clinical practice and research

K Makris, A Haliassos, M Chondrogianni… - Critical reviews in …, 2018 - Taylor & Francis
Fast and accurate diagnosis of stroke is crucial for the immediate application of the right
therapy to patients. However, rapid diagnosis is still a challenge since an ischemic stroke …

[HTML][HTML] Neutrophil-to-lymphocyte ratio predicts early neurological deterioration after endovascular treatment in patients with ischemic stroke

S Lattanzi, D Norata, S Broggi, S Meletti, M Świtońska… - Life, 2022 - mdpi.com
The worsening of neurological status that occurs early after acute ischemic stroke (AIS)
remains a serious issue, and the inflammatory response plays a key role in stroke …

Inflammatory molecules might become both biomarkers and therapeutic targets for stroke management

L Ramiro, A Simats… - Therapeutic …, 2018 - journals.sagepub.com
Stroke is the fifth leading cause of death and the most frequent cause of disability worldwide.
Currently, stroke diagnosis is based on neuroimaging; therefore, the lack of a rapid tool to …

[HTML][HTML] Tumor Necrosis Factor-α: The Next Marker of Stroke

Y Xue, X Zeng, WJ Tu, J Zhao - Disease markers, 2022 - hindawi.com
Although there is no shortage of research on the markers for stroke, to our knowledge, there
are no clear markers that can meet the needs of clinical prediction and treatment. The …

[HTML][HTML] Blood/brain biomarkers of inflammation after stroke and their association with outcome: from C-reactive protein to damage-associated molecular patterns

A Bustamante, A Simats, A Vilar-Bergua… - …, 2016 - Elsevier
Stroke represents one of the most important causes of disability and death in developed
countries. However, there is a lack of prognostic tools in clinical practice to monitor the …