[HTML][HTML] Pragmatic solutions to reduce the global burden of stroke: a World Stroke Organization–Lancet Neurology Commission
Executive summary Stroke is the second leading cause of death worldwide. The burden of
disability after a stroke is also large, and is increasing at a faster pace in low-income and …
disability after a stroke is also large, and is increasing at a faster pace in low-income and …
Mendelian randomization for cardiovascular diseases: principles and applications
SC Larsson, AS Butterworth… - European heart journal, 2023 - academic.oup.com
Large-scale genome-wide association studies conducted over the last decade have
uncovered numerous genetic variants associated with cardiometabolic traits and risk factors …
uncovered numerous genetic variants associated with cardiometabolic traits and risk factors …
High‐Performance Hydrogel Sensors Enabled Multimodal and Accurate Human–Machine Interaction System for Active Rehabilitation
H Wang, Q Ding, Y Luo, Z Wu, J Yu, H Chen… - Advanced …, 2024 - Wiley Online Library
Human–machine interaction (HMI) technology shows an important application prospect in
rehabilitation medicine, but it is greatly limited by the unsatisfactory recognition accuracy …
rehabilitation medicine, but it is greatly limited by the unsatisfactory recognition accuracy …
[HTML][HTML] The predominant PAR4 variant in individuals of African ancestry worsens murine and human stroke outcomes
F Denorme, ND Armstrong, ML Stoller… - The Journal of …, 2023 - Am Soc Clin Investig
Protease-activated receptor 4 (PAR4)(gene F2RL3) harbors a functional dimorphism,
rs773902 A/G (encoding Thr120/Ala120, respectively) and is associated with greater platelet …
rs773902 A/G (encoding Thr120/Ala120, respectively) and is associated with greater platelet …
A terminal metabolite of niacin promotes vascular inflammation and contributes to cardiovascular disease risk
Despite intensive preventive cardiovascular disease (CVD) efforts, substantial residual CVD
risk remains even for individuals receiving all guideline-recommended interventions. Niacin …
risk remains even for individuals receiving all guideline-recommended interventions. Niacin …
Reversal agents for current and forthcoming direct oral anticoagulants
Over the past 20 years, there has been a shift from vitamin K antagonists to direct oral
anticoagulants (DOACs), which include the thrombin inhibitor dabigatran and the factor Xa …
anticoagulants (DOACs), which include the thrombin inhibitor dabigatran and the factor Xa …
Stroke genetics: discovery, insight into mechanisms, and clinical perspectives
S Debette, HS Markus - Circulation Research, 2022 - Am Heart Assoc
Stroke is the second leading cause of death worldwide and a complex, heterogeneous
condition. In this review, we provide an overview of the current knowledge on monogenic …
condition. In this review, we provide an overview of the current knowledge on monogenic …
[HTML][HTML] The STROMICS genome study: deep whole-genome sequencing and analysis of 10K Chinese patients with ischemic stroke reveal complex genetic and …
S Cheng, Z Xu, S Bian, X Chen, Y Shi, Y Li, Y Duan… - Cell Discovery, 2023 - nature.com
Ischemic stroke is a leading cause of global mortality and long-term disability. However,
there is a paucity of whole-genome sequencing studies on ischemic stroke, resulting in …
there is a paucity of whole-genome sequencing studies on ischemic stroke, resulting in …
[HTML][HTML] Identification of novel protein biomarkers and drug targets for colorectal cancer by integrating human plasma proteome with genome
J Sun, J Zhao, F Jiang, L Wang, Q Xiao, F Han… - Genome medicine, 2023 - Springer
Background The proteome is a major source of therapeutic targets. We conducted a
proteome-wide Mendelian randomization (MR) study to identify candidate protein markers …
proteome-wide Mendelian randomization (MR) study to identify candidate protein markers …
Sex-specific genetic architecture of blood pressure
The genetic and genomic basis of sex differences in blood pressure (BP) traits remain
unstudied at scale. Here, we conducted sex-stratified and combined-sex genome-wide …
unstudied at scale. Here, we conducted sex-stratified and combined-sex genome-wide …