Disentangling mitochondria in Alzheimer's disease

A Johri - International journal of molecular sciences, 2021 - mdpi.com
Alzheimer's disease (AD) is a major cause of dementia in older adults and is fast becoming
a major societal and economic burden due to an increase in life expectancy. Age seems to …

Modulation of mitochondrial function as a therapeutic strategy for neurodegenerative diseases

E Trushina, TKO Nguyen, S Trushin - The journal of prevention of …, 2023 - Springer
Despite recent FDA approval of anti-amyloid antibodies for Alzheimer's Disease, strategies
that target early molecular mechanisms and could delay or change the disease trajectory …

GSH-AuNP anti-oxidative stress, ER stress and mitochondrial dysfunction in amyloid-beta peptide-treated human neural stem cells

MC Chiang, CJB Nicol - Free Radical Biology and Medicine, 2022 - Elsevier
Amyloid-beta (Aβ) peptides have a role in the pathogenesis of Alzheimer's disease (AD) and
are thought to promote oxidative stress, endoplasmic reticulum (ER) stress and …

Repurposing peroxisome proliferator-activated receptor agonists in neurological and psychiatric disorders

C Sagheddu, M Melis, AL Muntoni, M Pistis - Pharmaceuticals, 2021 - mdpi.com
Common pathophysiological mechanisms have emerged for different neurological and
neuropsychiatric conditions. In particular, mechanisms of oxidative stress, immuno …

New insights into the molecular interplay between human herpesviruses and Alzheimer's disease—a narrative review

E Athanasiou, AN Gargalionis, C Anastassopoulou… - Brain Sciences, 2022 - mdpi.com
Human herpesviruses (HHVs) have been implicated as possible risk factors in Alzheimer's
disease (AD) pathogenesis. Persistent lifelong HHVs infections may directly or indirectly …

PGC-1α activity and mitochondrial dysfunction in preterm infants

A Mohammadi, R Higazy, EB Gauda - Frontiers in Physiology, 2022 - frontiersin.org
Extremely low gestational age neonates (ELGANs) are born in a relatively hyperoxic
environment with weak antioxidant defenses, placing them at high risk for mitochondrial …

Exploring the common gene signatures and pathogeneses of obesity with Alzheimer's disease via transcriptome data

T Li, J Qu, C Xu, T Fang, B Sun, L Chen - Frontiers in Endocrinology, 2022 - frontiersin.org
Background Obesity is a complex condition that influences several organ systems and
physiologic systems. Obesity (OB) is closely linked to Alzheimer's disease (AD). However …

Age-Dependent Alterations of Cognition, Mitochondrial Function, and Beta-Amyloid Deposition in a Murine Model of Alzheimer's Disease—A Longitudinal Study

M Reutzel, R Grewal, A Joppe… - Frontiers in Aging …, 2022 - frontiersin.org
Aging is the main risk factor for sporadic Alzheimer's disease (AD), which is characterized by
the cerebral deposition of β-amyloid peptides (Aβ) and cognitive decline. Mitochondrial …

Exploring the Comprehensive Neuroprotective and Anticancer Potential of Afzelin

M Kciuk, N Garg, S Dhankhar, M Saini, S Mujwar… - Pharmaceuticals, 2024 - mdpi.com
Neurodegenerative diseases (Alzheimer's disease, Parkinson's disease, Huntington's
disease, and others) and cancer, seemingly disparate in their etiology and manifestation …

Molecular interplay between phytoconstituents of Ficus Racemosa and neurodegenerative diseases

A Rani, F Tabassum, AK Sharma - European Journal of …, 2024 - Wiley Online Library
Neurodegenerative diseases (NDs) are a significant global health concern, primarily
affecting middle and older populations. Recently, there has been growing interest in herbal …