Lifestyle interventions for the prevention and treatment of hypertension

PL Valenzuela, P Carrera-Bastos, BG Gálvez… - Nature Reviews …, 2021 - nature.com
Hypertension affects approximately one third of the world's adult population and is a major
cause of premature death despite considerable advances in pharmacological treatments …

Breath of life: the respiratory vagal stimulation model of contemplative activity

RJS Gerritsen, GPH Band - Frontiers in human neuroscience, 2018 - frontiersin.org
Contemplative practices, such as meditation and yoga, are increasingly popular among the
general public and as topics of research. Beneficial effects associated with these practices …

Strategies to increase nitric oxide signalling in cardiovascular disease

JO Lundberg, MT Gladwin, E Weitzberg - Nature reviews Drug …, 2015 - nature.com
Nitric oxide (NO) is a key signalling molecule in the cardiovascular, immune and central
nervous systems, and crucial steps in the regulation of NO bioavailability in health and …

European Guidelines on cardiovascular disease prevention in clinical practice (version 2012) The Fifth Joint Task Force of the European Society of Cardiology and …

European Journal of Preventive Cardiology, 2012 - journals.sagepub.com
Atherosclerotic cardiovascular disease (CVD) is a chronic disorder developing insidiously
throughout life and usually progressing to an advanced stage by the time symptoms occur. It …

Signaling pathways in vascular function and hypertension: molecular mechanisms and therapeutic interventions

J Ma, Y Li, X Yang, K Liu, X Zhang, X Zuo… - Signal transduction and …, 2023 - nature.com
Hypertension is a global public health issue and the leading cause of premature death in
humans. Despite more than a century of research, hypertension remains difficult to cure due …

Exercise modulates oxidative stress and inflammation in aging and cardiovascular diseases

N Sallam, I Laher - Oxidative medicine and cellular longevity, 2016 - Wiley Online Library
Despite the wealth of epidemiological and experimental studies indicating the protective role
of regular physical activity/exercise training against the sequels of aging and cardiovascular …

Effects of exercise training on chronic inflammation in obesity: current evidence and potential mechanisms

T You, NC Arsenis, BL Disanzo, MJ LaMonte - Sports Medicine, 2013 - Springer
Chronic, systemic inflammation is an independent risk factor for several major clinical
diseases. In obesity, circulating levels of inflammatory markers are elevated, possibly due to …

Cardiovascular risk factors and molecular routes underlying endothelial dysfunction: Novel opportunities for primary prevention

G Benincasa, E Coscioni, C Napoli - Biochemical Pharmacology, 2022 - Elsevier
One of the major challenges of cardiovascular primary prevention approach is the absence
of early biomarkers of endothelial dysfunction which may be useful for identifying at-risk …

How does exercise reduce the rate of age-associated cognitive decline? A review of potential mechanisms

G Kennedy, RJ Hardman… - Journal of …, 2017 - content.iospress.com
The rate of age-associated cognitive decline varies considerably between individuals. It is
important, both on a societal and individual level, to investigate factors that underlie these …

Vascular normalisation as the stepping stone into tumour microenvironment transformation

AL Magnussen, IG Mills - British journal of cancer, 2021 - nature.com
A functional vascular system is indispensable for drug delivery and fundamental for
responsiveness of the tumour microenvironment to such medication. At the same time, the …