In addition to proliferating cancer cells and various types of normal cells, such as those of
the bone marrow, conventional cytotoxic chemotherapeutics affect the endothelium of the …

Angiogenesis inhibitors are a new class of drugs, for which the general rules involving
conventional chemotherapy might not apply. The successful translation of angiogenesis …

To reveal the antiangiogenic capability of cancer chemotherapy, we developed an
alternative antiangiogenic schedule for administration of cyclophosphamide. We show here …

Metronomic chemotherapy, continuous and dose‐dense administration of chemotherapeutic
drugs with lowered doses, is being evaluated for substituting, augmenting, or appending …

This review assembles the laboratory and clinical evidence that cytotoxic chemotherapy and
antiangiogenic therapy are each dependent on endothelial cell apoptosis. During cytotoxic …

Purpose A transgenic mouse model has revealed parameters of the angiogenic switch
during multistep tumorigenesis of pancreatic islets, and demonstrated efficacy of …

Cancer-related death is a significant health and economic burden worldwide, and some
conventional chemotherapy is associated with limited effectiveness in completely curing …

One of the greatest barriers to the treatment of cancer with chemotherapeutic drugs is
acquisition of drug resistance. This includes multidrug resistance mediated by P …

Angiogenesis research is being translated to the clinic. Certain guidelines may facilitate this
effort. Recruitment of endothelial cells by a tumor is an early event in angiogenesis, a …

Modern chemistry is vastly fascinated by dendrimer chemistry, an area that is rapidly
expanding and brimming with potential applications. Dendrimers are highly branched …