[HTML][HTML] Interactions between NSAIDs, opioids and the gut microbiota-future perspectives in the management of inflammation and pain

ZS Zádori, K Király, M Al-Khrasani, K Gyires - Pharmacology & Therapeutics, 2023 - Elsevier
The composition of intestinal microbiota is influenced by a number of factors, including
medications, which may have a substantial impact on host physiology. Nonsteroidal anti …

[HTML][HTML] Therapeutic potential of butyrate for treatment of type 2 diabetes

T Arora, V Tremaroli - Frontiers in endocrinology, 2021 - frontiersin.org
Metagenomics studies have shown that type 2 diabetes (T2D) is associated with an altered
gut microbiota. Whereas different microbiota patterns have been observed in independent …

[HTML][HTML] The importance of the gut microbiome and its signals for a healthy nervous system and the multifaceted mechanisms of neuropsychiatric disorders

L Riehl, J Fürst, M Kress, N Rykalo - Frontiers in Neuroscience, 2024 - frontiersin.org
Increasing evidence links the gut microbiome and the nervous system in health and disease.
This narrative review discusses current views on the interaction between the gut microbiota …

The contribution of age-related changes in the gut-brain axis to neurological disorders

R Khan, CM Di Gesù, J Lee, LD McCullough - Gut microbes, 2024 - Taylor & Francis
Trillions of microbes live symbiotically in the host, specifically in mucosal tissues such as the
gut. Recent advances in metagenomics and metabolomics have revealed that the gut …

[HTML][HTML] Host-diet-gut microbiome interactions influence human energy balance: a randomized clinical trial

KD Corbin, EA Carnero, B Dirks, D Igudesman… - Nature …, 2023 - nature.com
The gut microbiome is emerging as a key modulator of human energy balance. Prior studies
in humans lacked the environmental and dietary controls and precision required to …

[HTML][HTML] Microbial metabolite p-cresol inhibits gut hormone expression and regulates small intestinal transit in mice

PB Toft, AM Vanslette, K Trošt, T Moritz… - Frontiers in …, 2023 - frontiersin.org
p-cresol is a metabolite produced by microbial metabolism of aromatic amino acid tyrosine.
p-cresol and its conjugated forms, p-cresyl sulfate and p-cresyl glucuronide, are uremic …

Gut microbiota: Candidates for a novel strategy for ameliorating sleep disorders

L Li, T Liang, T Jiang, Y Li, L Yang, L Wu… - Critical Reviews in …, 2023 - Taylor & Francis
The aim of this review was to evaluate the feasibility of treating sleep disorders using novel
gut microbiota intervention strategies. Multiple factors can cause sleep disorders, including …

Our extended microbiome: The human-relevant metabolites and biology of fermented foods

EB Caffrey, JL Sonnenburg, S Devkota - Cell Metabolism, 2024 - cell.com
One of the key modes of microbial metabolism occurring in the gut microbiome is
fermentation. This energy-yielding process transforms common macromolecules like …

[HTML][HTML] Biomimetic nanocarriers harnessing microbial metabolites usher the path for brain disease therapy

Y Gong, Z Liu, P Zhou, J Li, YB Miao - Nano TransMed, 2023 - Elsevier
The gastrointestinal system, often regarded as the'second brain of humanity,'maintains a
profound connection with the cerebral realm. Unlocking the intricate metabolic pathways of …

Serotonin receptor 4 agonism prevents high fat diet induced reduction in GLP-1 in mice

AM Vanslette, PB Toft, ML Lund, T Moritz… - European Journal of …, 2023 - Elsevier
Hormone-producing enteroendocrine cells (EECs) are present throughout the
gastrointestinal tract and respond to various nutrient and gut microbiota produced …