Microsatellite instability (MSI) is a molecular marker of a deficient mismatch repair (MMR)
system and occurs in approximately 15% of colorectal cancers (CRCs), more frequently in …

Background: Deficient mismatch repair (dMMR) colon cancer (CC) is reportedly resistant to
5-fluorouracil (5FU) adjuvant chemotherapy while preliminary data suggest chemosensitivity …

Adjuvant chemotherapy can be considered in high‐risk stage II colon cancer comprising
pT4, poor/undifferentiated grade, vascular invasion, emergency surgery and/or< 10 …

Simple Summary Lynch syndrome is characterized by a higher relative risk of developing
certain cancers, especially digestive cancers. Many guidelines from different scientific …

Immune checkpoint inhibitors have failed in treating metastatic colorectal cancer (mCRC)
patients except those with dMMR/MSI tumors. However, until very recently we had only non …

INTRODUCTION—Carcinoma of the colon or rectum (colorectal cancer [CRC]) is a common
malignancy. Surgical resection is the primary treatment modality for early stage CRC (stage I …

Colorectal cancers (CRCs) exhibiting microsatellite instability (MSI) have special biological
behavior. The clinical predictors for MSI and its survival relevance for the Chinese …

Introduction This article is a summary of the French intergroup guidelines regarding the
management of non-metastatic colon cancer (CC), revised in November 2022. Methods …

Kristen rat sarcoma viral oncogene homolog (KRAS) and microsatellite instability (MSI) are
prognostic markers of colorectal cancer (CRC). However, the clinical value is still not fully …

Background For high-risk stageIImismatch repair deficient (dMMR) colon cancers, the
benefit of adjuvant chemotherapy remains debatable. The principal aim of this study was to …