Introduction: Uremic syndrome of chronic kidney disease (CKD) is a term used to describe
clinical, metabolic, and hormonal abnormalities associated with progressive kidney failure. It …

Chronic kidney disease (CKD) is a critical and rapidly growing global health problem.
Neurological complications occur in almost all patients with severe CKD, potentially affecting …

Dysfunction of the circadian clock has been implicated in the pathogenesis of cardiovascular
disease. The CLOCK protein is a core molecular component of the circadian oscillator, so …

Conservative kidney management is increasingly accepted as an appropriate treatment
option for patients with eGFR category 5 CKD who are unlikely to benefit from dialysis and/or …

BACKGROUND: Despite being frequently described in patients with end-stage renal
disease (ESRD), clinical characteristics and comorbidities in association with restless legs …

Restless legs syndrome (RLS)(or Willis–Ekbom disease) is a neurological disorder with high
prevalence among the end-stage renal disease population. This is one of the most …

Symptoms of restless legs syndrome (RLS) are common in patients with chronic kidney
disease (CKD) on dialysis; symptoms of RLS are estimated to affect up to 25% of patients on …

Objective: This narrative review describes the differential diagnosis of restless legs
syndrome, and provides an overview of the evidence for the associations between RLS and …

Background Sleep disorders are very common in patients with chronic kidney disease and
they may not always subside after kidney transplantation. Aim and methods The aim of this …

Background Restless legs syndrome (RLS) is a sleep related movement disorder that occurs
both in an idiopathic form and in symptomatic varieties. RLS is a frequent and distressing …