Serotonin is perhaps best known as a neurotransmitter that modulates neural activity and a
wide range of neuropsychological processes, and drugs that target serotonin receptors are …

The superfamily of G-protein-coupled receptors (GPCRs) could be subclassified into 7
families (A, B, large N-terminal family B-7 transmembrane helix, C, Frizzled/Smoothened …

Drug-target interaction (DTI) is the basis of drug discovery and design. It is time consuming
and costly to determine DTI experimentally. Hence, it is necessary to develop computational …

Serotonin or 5-hydroxytryptamine (5-HT) regulates a wide spectrum of human physiology
through the 5-HT receptor family. We report the crystal structures of the human 5-HT1B G …

The identification of protein function based on biological information is an area of intense
research. Here we consider a complementary technique that quantitatively groups and …

An inverse relationship between brain serotonin and food intake and body weight has been
known for more than 30years. Specifically, augmentation of brain serotonin inhibits food …

Abstract The central serotonin (5-HT) neurotransmitter system is an important modulator of
diverse physiological processes and behaviors; however, the transcriptional mechanisms …

It was recently discovered that mammalian skin can produce serotonin and transform it into
melatonin. Pathways for the biosynthesis and biodegradation of serotonin and melatonin …

Motivation: In silico prediction of drug-target interactions plays an important role toward
identifying and developing new uses of existing or abandoned drugs. Network-based …

Carcinoid heart disease was one of the first valvular pathologies studied in molecular detail,
and early research identified serotonin produced by oncogenic enterochromaffin cells as the …