Stemness in cancer: stem cells, cancer stem cells, and their microenvironment

PM Aponte, A Caicedo - Stem cells international, 2017 - Wiley Online Library
Stemness combines the ability of a cell to perpetuate its lineage, to give rise to differentiated
cells, and to interact with its environment to maintain a balance between quiescence …

Differences and similarities between cancer and somatic stem cells: therapeutic implications

F Rossi, H Noren, R Jove, V Beljanski… - Stem cell research & …, 2020 - Springer
Over the last decades, the cancer survival rate has increased due to personalized therapies,
the discovery of targeted therapeutics and novel biological agents, and the application of …

The effect of 2D and 3D cell cultures on treatment response, EMT profile and stem cell features in head and neck cancer

S Melissaridou, E Wiechec, M Magan, MV Jain… - Cancer cell …, 2019 - Springer
Abstract Background Head and Neck Squamous Cell Carcinoma (HNSCC) tumors are often
resistant to therapies. Therefore searching for predictive markers and new targets for …

[HTML][HTML] Lipid metabolism alteration contributes to and maintains the properties of cancer stem cells

H Li, Z Feng, ML He - Theranostics, 2020 - ncbi.nlm.nih.gov
Lipids, the basic components of the cell membrane, execute fundamental roles in almost all
the cell activities including cell-cell recognition, signalling transduction and energy supplies …

Mechanisms of the Epithelial–Mesenchymal Transition and Tumor Microenvironment in Helicobacter pylori-Induced Gastric Cancer

J Baj, I Korona-Głowniak, A Forma, A Maani, E Sitarz… - Cells, 2020 - mdpi.com
Helicobacter pylori (H. pylori) is one of the most common human pathogens, affecting half of
the world's population. Approximately 20% of the infected patients develop gastric ulcers or …

Inhibition of VEGF binding to neuropilin-2 enhances chemosensitivity and inhibits metastasis in triple-negative breast cancer

Z Xu, HL Goel, C Burkart, L Burman… - Science translational …, 2023 - science.org
Although blocking the binding of vascular endothelial growth factor (VEGF) to neuropilin-2
(NRP2) on tumor cells is a potential strategy to treat aggressive carcinomas, a lack of …

Focus on formononetin: anticancer potential and molecular targets

SKL Ong, MK Shanmugam, L Fan, SE Fraser, F Arfuso… - Cancers, 2019 - mdpi.com
Formononetin, an isoflavone, is extracted from various medicinal plants and herbs, including
the red clover (Trifolium pratense) and Chinese medicinal plant Astragalus membranaceus …

CD44/CD44v6 a reliable companion in cancer-initiating cell maintenance and tumor progression

Z Wang, K Zhao, T Hackert, M Zöller - Frontiers in cell and …, 2018 - frontiersin.org
Metastasis is the leading cause of cancer death, tumor progression proceeding through
emigration from the primary tumor, gaining access to the circulation, leaving the circulation …

LncRNA SNHG5 promotes the proliferation and cancer stem cell-like properties of HCC by regulating UPF1 and Wnt-signaling pathway

Y Li, J Hu, D Guo, W Ma, X Zhang, Z Zhang, G Lu… - Cancer gene …, 2022 - nature.com
The role of long noncoding RNA (lncRNAs) had been demonstrated in different types of
cancer, including hepatocellular carcinoma. This study was intended to investigate the role …

EMT‐and MET‐related processes in nonepithelial tumors: importance for disease progression, prognosis, and therapeutic opportunities

UD Kahlert, JV Joseph, FAE Kruyt - Molecular oncology, 2017 - Wiley Online Library
The epithelial‐to mesenchymal (EMT) process is increasingly recognized for playing a key
role in the progression, dissemination, and therapy resistance of epithelial tumors …