Targeting integrin pathways: mechanisms and advances in therapy
X Pang, X He, Z Qiu, H Zhang, R Xie, Z Liu… - … and Targeted Therapy, 2023 - nature.com
Integrins are considered the main cell-adhesion transmembrane receptors that play
multifaceted roles as extracellular matrix (ECM)-cytoskeletal linkers and transducers in …
multifaceted roles as extracellular matrix (ECM)-cytoskeletal linkers and transducers in …
Extracellular matrix in kidney fibrosis: more than just a scaffold
Kidney fibrosis is the common histological end-point of progressive, chronic kidney diseases
(CKDs) regardless of the underlying etiology. The hallmark of renal fibrosis, similar to all …
(CKDs) regardless of the underlying etiology. The hallmark of renal fibrosis, similar to all …
Cell biology of the glomerular podocyte
H Pavenstadt, W Kriz, M Kretzler - Physiological reviews, 2003 - journals.physiology.org
Glomerular podocytes are highly specialized cells with a complex cytoarchitecture. Their
most prominent features are interdigitated foot processes with filtration slits in between …
most prominent features are interdigitated foot processes with filtration slits in between …
Dedifferentiation and proliferation of surviving epithelial cells in acute renal failure
JV Bonventre - Journal of the American Society of Nephrology, 2003 - journals.lww.com
In contrast to the heart or brain, the kidney can completely recover from an ischemic or toxic
insult that results in cell death. During recovery from ischemia/reperfusion injury, surviving …
insult that results in cell death. During recovery from ischemia/reperfusion injury, surviving …
Shedding of kidney injury molecule-1, a putative adhesion protein involved in renal regeneration
V Bailly, Z Zhang, W Meier, R Cate, M Sanicola… - Journal of Biological …, 2002 - ASBMB
KIM-1 (kidney injury molecule-1) is a type I transmembrane glycoprotein expressed on
dedifferentiated renal proximal tubule epithelial cells undergoing regeneration after toxic or …
dedifferentiated renal proximal tubule epithelial cells undergoing regeneration after toxic or …
[PDF][PDF] Structural organization of the mammalian kidney
W Kriz, B Kaissling - The kidney: physiology and pathophysiology, 1992 - researchgate.net
The mammalian kidney is multiform. The basic architecture is best understood in the
unipapillary kidney, which is common in all small species. A coronal section of this kidney …
unipapillary kidney, which is common in all small species. A coronal section of this kidney …
Podocyte biology and pathogenesis of kidney disease
Proteinuric chronic kidney disease (CKD), once a rare affliction believed to be mainly
caused by genetic mutations, has become a global pandemic that severely diminishes the …
caused by genetic mutations, has become a global pandemic that severely diminishes the …
Nanoscale protein architecture of the kidney glomerular basement membrane
In multicellular organisms, proteins of the extracellular matrix (ECM) play structural and
functional roles in essentially all organs, so understanding ECM protein organization in …
functional roles in essentially all organs, so understanding ECM protein organization in …
Role of triglyceride-rich lipoproteins in diabetic nephropathy
JC Rutledge, KF Ng, HH Aung… - Nature Reviews …, 2010 - nature.com
Diabetic nephropathy is an increasingly important cause of morbidity and mortality
worldwide. A large body of evidence suggests that dyslipidemia has an important role in the …
worldwide. A large body of evidence suggests that dyslipidemia has an important role in the …
[HTML][HTML] β1 integrin expression by podocytes is required to maintain glomerular structural integrity
A Pozzi, G Jarad, GW Moeckel, S Coffa, X Zhang… - Developmental …, 2008 - Elsevier
Integrins are transmembrane heteromeric receptors that mediate interactions between cells
and extracellular matrix (ECM). β1, the most abundantly expressed integrin subunit, binds at …
and extracellular matrix (ECM). β1, the most abundantly expressed integrin subunit, binds at …