Cancer progression with uncontrolled tumor growth, local invasion, and metastasis depends
largely on the proteolytic activity of numerous matrix metalloproteinases (MMPs), which …

Head and neck squamous cell carcinomas (HNSCCs) are caused by tobacco and alcohol
consumption and by infection with high-risk types of human papillomavirus (HPV). Tumours …

The tumor microenvironment (TME) of head and neck squamous cell carcinoma (HNSCC) is
comprised of cancer-associated fibroblasts (CAFs), immune cells, and other supporting …

Matrix metalloproteinases (MMPs) are zinc-dependent endopeptidases that regulate the
turnover of extracellular matrix (ECM) components. Gross and La Piere discovered MMPs in …

Invadopodia are branched actin-rich structures associated with extracellular matrix (ECM)
degradation that collectively form the invasive machinery of aggressive cancer cells …

Background The head and neck/oral squamous cell carcinoma (HNOSCC) is a diverse
group of cancers, which develop from many different anatomic sites and are associated with …

EGFR is a potent stimulator of invasion and metastasis in head and neck squamous cell
carcinomas (HNSCC). However, the mechanism by which EGFR may stimulate tumor cell …

Matrix metalloproteinases (MMPs) are identifiable members of proteolytic enzymes that can
degrade a wide range of proteins in the extracellular matrix (ECM). MMPs can be …

Nasopharyngeal carcinoma (NPC) is a head and neck cancer rare throughout most of the
world but common in certain geographic areas, such as southern Asia. While environmental …

Background: Previous studies have demonstrated that senescent cancer-associated
fibroblasts (CAFs) derived from genetically unstable oral squamous cell carcinomas (GU …