Inter-individual genomic variations have recently become evident with advances in
sequencing techniques and genome-wide array comparative genomic hybridization. Among …

NRXN1 undergoes extensive alternative splicing, and non-recurrent heterozygous deletions
in NRXN1 are strongly associated with neuropsychiatric disorders. We establish that human …

Neurexins are a family of presynaptic single-pass transmembrane proteins that act as
synaptic organizers in mammals. The neurexins consist of three genes (NRXN1, NRXN2 …

The ability of chromosome microarray analysis (CMA) to detect submicroscopic genetic
abnormalities has revolutionized the clinical diagnostic approach to individuals with …

RNA editing critically regulates neurodevelopment and normal neuronal function. The global
landscape of RNA editing was surveyed across 364 schizophrenia cases and 383 control …

The term neurodevelopmental disorder encompasses a wide range of diseases, including
recognizably distinct syndromes known to be caused by very rare mutations in specific …

Perturbations of cell surface synapse-organizing proteins, particularly α-neurexins,
contribute to neurodevelopmental and psychiatric disorders. From an unbiased screen, we …

While germline copy-number variants (CNVs) contribute to schizophrenia (SCZ) risk, the
contribution of somatic CNVs (sCNVs)—present in some but not all cells—remains …

The link between bipolar disorder (BP) and immune dysfunction remains controversial.
While epidemiological studies have long suggested an association, recent research has …

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