COX 2-inhibitors; a thorough and updated survey into combinational therapies in cancers
Cyclooxygenase (COX) enzymes are pivotal in inflammation and cancer development. COX-
2, in particular, has been implicated in tumor growth, angiogenesis, and immune evasion …
2, in particular, has been implicated in tumor growth, angiogenesis, and immune evasion …
[HTML][HTML] PROTACs in the management of prostate cancer
P Yedla, AO Babalghith, VV Andra, R Syed - Molecules, 2023 - mdpi.com
Cancer treatments with targeted therapy have gained immense interest due to their low
levels of toxicity and high selectivity. Proteolysis-Targeting Chimeras (PROTACs) have …
levels of toxicity and high selectivity. Proteolysis-Targeting Chimeras (PROTACs) have …
[HTML][HTML] Molecular docking evaluation of celecoxib on the boron nitride nanostructures for alleviation of cardiovascular risk and inflammatory
Y Cao, M Noori, M Nazari, ANK Lup, A Soltani… - Arabian Journal of …, 2022 - Elsevier
Celecoxib (CXB) is a nonsteroidal anti-inflammatory drug (NSAID) that can be used to treat
rheumatoid arthritis and ischemic heart disease. In this research, density functional theory …
rheumatoid arthritis and ischemic heart disease. In this research, density functional theory …
[HTML][HTML] Lactobacillus plantarum Zhang-LL Inhibits Colitis-Related Tumorigenesis by Regulating Arachidonic Acid Metabolism and CD22-Mediated B-Cell Receptor …
J Zhu, W Liu, Z Bian, Y Ma, Z Kang, J Jin, X Li, S Ge… - Nutrients, 2023 - mdpi.com
Colorectal cancer (CRC) is a significant health concern and is the third most commonly
diagnosed and second deadliest cancer worldwide. CRC has been steadily increasing in …
diagnosed and second deadliest cancer worldwide. CRC has been steadily increasing in …
[HTML][HTML] Novel Benzo[4,5]imidazo[1,2-a]pyrimidine derivatives as selective Cyclooxygenase-2 Inhibitors: Design, synthesis, docking studies, and biological evaluation
The present study was aimed at the synthesis and evaluation of a new series of benzo [4, 5]
imidazo [1, 2-a] pyrimidine having a methylsulfonyl group as COX-2 (cyclooxygenase-2) …
imidazo [1, 2-a] pyrimidine having a methylsulfonyl group as COX-2 (cyclooxygenase-2) …
PARs in the inflammation-cancer transformation of CRC
J Lv, J Liu, G Chao, S Zhang - Clinical and Translational Oncology, 2023 - Springer
Colorectal cancer (CRC) is one of the common malignancies with a global trend of
increasing incidence and mortality. There is an urgent need to identify new predictive …
increasing incidence and mortality. There is an urgent need to identify new predictive …
[HTML][HTML] Integrated gut microbiota and metabolome analysis reveals the mechanism of Xiaoai Jiedu recipe in ameliorating colorectal cancer
W Qiu, H Xie, H Chen, H Zhou, Z Wang… - Frontiers in …, 2023 - frontiersin.org
Introduction Xiaoai Jiedu recipe (XJR), a classical prescription of traditional Chinese
medicine (TCM), has been clinically proven to be effective in ameliorating colorectal cancer …
medicine (TCM), has been clinically proven to be effective in ameliorating colorectal cancer …
Trust Your Gut: Strategies and Tactics for Intestinally Restricted Drugs
R Dorel, AR Wong, JJ Crawford - ACS Medicinal Chemistry Letters, 2023 - ACS Publications
Non-absorbable small-molecule drugs targeted to the gut represent an alternative approach
to safe, non-systemic therapeutics. Such drugs remain confined to the gastrointestinal tract …
to safe, non-systemic therapeutics. Such drugs remain confined to the gastrointestinal tract …
[HTML][HTML] Mechanism study of oleanolic acid derivative, K73-03, inducing cell apoptosis in hepatocellular carcinoma
Abstract Oleanolic acid (3β-hydroxyolean-12-en-28-oic acid, OA) is a kind of pentacyclic
triterpene, which widely distributes in nature. OA possesses a powerful anti-cancer effect; …
triterpene, which widely distributes in nature. OA possesses a powerful anti-cancer effect; …
[HTML][HTML] Retrospective efficacy analysis of olaparib combined with bevacizumab in the treatment of advanced colorectal cancer
YL Jiang, XY Fu, ZH Yin - World Journal of Gastrointestinal Surgery, 2023 - ncbi.nlm.nih.gov
BACKGROUND Colorectal cancer (CRC) is a highly prevalent malignancy of the digestive
tract worldwide, characterized by a significant morbidity and mortality rate and subtle initial …
tract worldwide, characterized by a significant morbidity and mortality rate and subtle initial …