Rheumatoid arthritis (RA) is a systemic and heterogeneous autoimmune disease with
symmetrical polyarthritis as its critical clinical manifestation. The basic cause of autoimmune …

DNA methylation is a dynamic epigenetic modification with a prominent role in determining
mammalian cell development, lineage identity, and transcriptional regulation. Primarily …

Adoptive transfer of regulatory T cells (Tregs) is therapeutic in type 1 diabetes (T1D) mouse
models. Tregs that are specific for pancreatic islets are more potent than polyclonal Tregs in …

Extracellular adenosine-dependent suppression and redirection of pro-inflammatory
activities are mediated by the signaling through adenosine receptors on the surface of most …

Regulatory T cells (Tregs) are suppressive T cells that have an essential role in maintaining
the balance between immune activation and tolerance. Their development, either in the …

Foxp3+ Tregs are central regulators of immune tolerance. As dysregulated Treg responses
contribute to disease pathogenesis, novel approaches to target the immunomodulatory …

Rationale: Pulmonary arterial hypertension (PH) is a life-threatening condition associated
with immune dysregulation and abnormal regulatory T cell (Treg) activity, but it is currently …

Tregs require Foxp3 expression and induction of a specific DNA hypomethylation signature
during development, after which Tregs persist as a self-renewing population that regulates …

Abstract CD4+ CD25+ Foxp3+ regulatory cells (T regs) are a special lineage of cells central
in the maintenance of immune homeostasis, and are targeted for human immunotherapy …

Regulatory T (Treg) cells control self-tolerance, inflammatory responses and tissue
homeostasis. In mature Treg cells, continued expression of FOXP3 maintains lineage …