Melanoma develops from malignant transformations of the pigment-producing melanocytes.
If located in the basal layer of the skin epidermis, melanoma is referred to as cutaneous …

Apoptosis is an ordered and orchestrated cellular process that occurs in physiological and
pathological conditions. It is also one of the most studied topics among cell biologists. An …

Zebrafish have been widely used as a model system for studying developmental processes,
but in the last decade, they have also emerged as a valuable system for modeling human …

Rounded-amoeboid cancer cells use actomyosin contractility driven by Rho-ROCK and JAK-
STAT3 to migrate efficiently. It has been suggested that rounded-amoeboid cancer cells do …

The high number of somatic mutations in the melanoma genome associated with cumulative
ultra violet (UV) exposure has rendered it one of the most difficult of cancers to treat. With …

Nearly 90% of human melanomas contain inactivated wild-type p53, the underlying
mechanisms for which are not fully understood. Here, we identify that cyclin B1/CDK1 …

ROCK-Myosin II drives fast rounded-amoeboid migration in cancer cells during metastatic
dissemination. Analysis of human melanoma biopsies revealed that amoeboid melanoma …

Background The emergence of high-throughput genomic datasets from different sources
and platforms (eg, gene expression, single nucleotide polymorphisms (SNP), and copy …

Simple Summary Recent research suggests a strong link between the functioning of
mitochondria and the development of cancer. Healthy mitochondria play a vital role in …

Notoriously resistant malignant melanoma is one of the most increasing forms of cancer
worldwide; there is thus a precarious need for new treatment options. The Wee1 kinase is a …