Multiple sclerosis: Neuroimmune crosstalk and therapeutic targeting

M Charabati, MA Wheeler, HL Weiner, FJ Quintana - Cell, 2023 - cell.com
Multiple sclerosis (MS) is a chronic inflammatory and degenerative disease of the central
nervous system afflicting nearly three million individuals worldwide. Neuroimmune …

Gut microbiota interact with the brain through systemic chronic inflammation: implications on neuroinflammation, neurodegeneration, and aging

Y Mou, Y Du, L Zhou, J Yue, X Hu, Y Liu… - Frontiers in …, 2022 - frontiersin.org
It has been noticed in recent years that the unfavorable effects of the gut microbiota could
exhaust host vigor and life, yet knowledge and theory are just beginning to be established …

Fecal microbiota transplantation protects rotenone-induced Parkinson's disease mice via suppressing inflammation mediated by the lipopolysaccharide-TLR4 …

Z Zhao, J Ning, X Bao, M Shang, J Ma, G Li, D Zhang - Microbiome, 2021 - Springer
Background Parkinson's disease (PD) is a prevalent neurodegenerative disorder, displaying
not only well-known motor deficits but also gastrointestinal dysfunctions. Consistently, it has …

Gut microbiome of multiple sclerosis patients and paired household healthy controls reveal associations with disease risk and course

X Zhou, R Baumann, X Gao, M Mendoza, S Singh… - Cell, 2022 - cell.com
Changes in gut microbiota have been associated with several diseases. Here, the
International Multiple Sclerosis Microbiome Study (iMSMS) studied the gut microbiome of …

Impact of the mother's gut microbiota on infant microbiome and brain development

EA Mady, AS Doghish, WA El-Dakroury… - Neuroscience & …, 2023 - Elsevier
The link between the gut microbiome and health has recently garnered considerable interest
in its employment for medicinal purposes. Since the early microbiota exhibits more flexibility …

Deficient butyrate-producing capacity in the gut microbiome is associated with bacterial network disturbances and fatigue symptoms in ME/CFS

C Guo, X Che, T Briese, A Ranjan, O Allicock… - Cell host & …, 2023 - cell.com
Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is characterized by
unexplained debilitating fatigue, cognitive dysfunction, gastrointestinal disturbances, and …

The role of the gut microbiota in multiple sclerosis

J Correale, R Hohlfeld, SE Baranzini - Nature Reviews Neurology, 2022 - nature.com
During the past decade, research has revealed that the vast community of micro-organisms
that inhabit the gut—known as the gut microbiota—is intricately linked to human health and …

Lactobacillus reuteri tryptophan metabolism promotes host susceptibility to CNS autoimmunity

TL Montgomery, K Eckstrom, KH Lile, S Caldwell… - Microbiome, 2022 - Springer
Background Dysregulation of gut microbiota-associated tryptophan metabolism has been
observed in patients with multiple sclerosis. However, defining direct mechanistic links …

Ageing and multiple sclerosis

JS Graves, KM Krysko, LH Hua, M Absinta… - The Lancet …, 2023 - thelancet.com
The factor that is most relevant and strongly associated with the clinical course of multiple
sclerosis is chronological age. Very young patients exclusively have relapsing remitting …

Thinking outside the box: non-canonical targets in multiple sclerosis

L Bierhansl, HP Hartung, O Aktas, T Ruck… - Nature reviews Drug …, 2022 - nature.com
Multiple sclerosis (MS) is an immune-mediated disease of the central nervous system that
causes demyelination, axonal degeneration and astrogliosis, resulting in progressive …