Trypanosoma cruzi genetic diversity: Something new for something known about Chagas disease manifestations, serodiagnosis and drug sensitivity

B Zingales - Acta tropica, 2018 - Elsevier
The genetic diversity of Trypanosoma cruzi, the protozoan agent of Chagas disease, is
widely recognized. At present, T. cruzi is partitioned into seven discrete typing units (DTUs) …

An Updated View of the Trypanosoma cruzi Life Cycle: Intervention Points for an Effective Treatment

J Martín-Escolano, C Marín, MJ Rosales… - ACS Infectious …, 2022 - ACS Publications
Chagas disease (CD) is a parasitic, systemic, chronic, and often fatal illness caused by
infection with the protozoan Trypanosoma cruzi. The World Health Organization classifies …

[HTML][HTML] Experimental and clinical treatment of Chagas disease: a review

PAS Junior, I Molina, SMF Murta… - The American journal …, 2017 - ncbi.nlm.nih.gov
Chagas disease (CD) is caused by the protozoan parasite Trypanosoma cruzi that infects a
broad range of triatomines and mammalian species, including man. It afflicts 8 million …

Treatment of adult chronic indeterminate Chagas disease with benznidazole and three E1224 dosing regimens: a proof-of-concept, randomised, placebo-controlled …

F Torrico, J Gascon, L Ortiz, C Alonso-Vega… - The Lancet Infectious …, 2018 - thelancet.com
Background Chagas disease is a major neglected vector-borne disease. In this study, we
investigated the safety and efficacy of three oral E1224 (a water-soluble ravuconazole …

Randomized trial of posaconazole and benznidazole for chronic Chagas' disease

I Molina, J Gómez i Prat, F Salvador… - … England Journal of …, 2014 - Mass Medical Soc
Background Current therapeutic options for Chagas' disease are limited to benznidazole
and nifurtimox, which have been associated with low cure rates in the chronic stage of the …

[PDF][PDF] The potential of secondary metabolites from plants as drugs or leads against protozoan neglected diseases-part II

TJ Schmidt, SA Khalid, AJ Romanha, TMA Alves… - 2012 - lavierebelle.org
Infections with protozoan parasites are a major cause of disease and mortality in many
tropical countries of the world. Diseases caused by species of the genera Trypanosoma …

Antitrypanosomal therapy for chronic Chagas' disease

C Bern - New England Journal of Medicine, 2011 - Mass Medical Soc
Antitrypanosomal Therapy for Chronic Chagas' Disease | New England Journal of Medicine Skip
to main content The New England Journal of Medicine homepage Advanced Search SEARCH …

Recent clinical trials for the etiological treatment of chronic Chagas disease: advances, challenges and perspectives

JA Urbina - Journal of Eukaryotic Microbiology, 2015 - Wiley Online Library
Chagas disease, a chronic systemic parasitosis caused by the Kinetoplastid protozoon
Trypanosoma cruzi, is the first cause of cardiac morbidity and mortality in poor rural and …

Nitroheterocyclic compounds are more efficacious than CYP51 inhibitors against Trypanosoma cruzi: implications for Chagas disease drug discovery and …

CB Moraes, MA Giardini, H Kim, CH Franco… - Scientific reports, 2014 - nature.com
Advocacy for better drugs and access to treatment has boosted the interest in drug discovery
and development for Chagas disease, a chronic infection caused by the genetically …

Searching for drugs for Chagas disease, leishmaniasis and schistosomiasis: a review

SS Santos, RV de Araújo, J Giarolla, O El Seoud… - International journal of …, 2020 - Elsevier
Chagas disease, leishmaniasis and schistosomiasis are neglected diseases (NDs) and are
a considerable global challenge. Despite the huge number of people infected, NDs do not …