Post-traumatic stress disorder: clinical and translational neuroscience from cells to circuits
Post-traumatic stress disorder (PTSD) is a maladaptive and debilitating psychiatric disorder,
characterized by re-experiencing, avoidance, negative emotions and thoughts, and …
characterized by re-experiencing, avoidance, negative emotions and thoughts, and …
Structure, function, and pharmacology of glutamate receptor ion channels
Many physiologic effects of l-glutamate, the major excitatory neurotransmitter in the
mammalian central nervous system, are mediated via signaling by ionotropic glutamate …
mammalian central nervous system, are mediated via signaling by ionotropic glutamate …
The oxytocin receptor: from intracellular signaling to behavior
B Jurek, ID Neumann - Physiological reviews, 2018 - journals.physiology.org
The many facets of the oxytocin (OXT) system of the brain and periphery elicited nearly
25,000 publications since 1930 (see, as listed in PubMed), which revealed central roles for …
25,000 publications since 1930 (see, as listed in PubMed), which revealed central roles for …
Neuropharmacological modulation of N-methyl-D-aspartate, noradrenaline and endocannabinoid receptors in fear extinction learning: Synaptic transmission and …
S Battaglia, C Di Fazio, CM Vicario… - International Journal of …, 2023 - mdpi.com
Learning to recognize and respond to potential threats is crucial for survival. Pavlovian
threat conditioning represents a key paradigm for investigating the neurobiological …
threat conditioning represents a key paradigm for investigating the neurobiological …
Inflammation in fear-and anxiety-based disorders: PTSD, GAD, and beyond
The study of inflammation in fear-and anxiety-based disorders has gained interest as
growing literature indicates that pro-inflammatory markers can directly modulate affective …
growing literature indicates that pro-inflammatory markers can directly modulate affective …
Behavioral and neurobiological mechanisms of pavlovian and instrumental extinction learning
This article reviews the behavioral neuroscience of extinction, the phenomenon in which a
behavior that has been acquired through Pavlovian or instrumental (operant) learning …
behavior that has been acquired through Pavlovian or instrumental (operant) learning …
Fear memory
I Izquierdo, CRG Furini, JC Myskiw - Physiological reviews, 2016 - journals.physiology.org
Fear memory is the best-studied form of memory. It was thoroughly investigated in the past
60 years mostly using two classical conditioning procedures (contextual fear conditioning …
60 years mostly using two classical conditioning procedures (contextual fear conditioning …
[HTML][HTML] Novel pharmacological targets in drug development for the treatment of anxiety and anxiety-related disorders
SB Sartori, N Singewald - Pharmacology & therapeutics, 2019 - Elsevier
Current medication for anxiety disorders is suboptimal in terms of efficiency and tolerability,
highlighting the need for improved drug treatments. In this review an overview of drugs …
highlighting the need for improved drug treatments. In this review an overview of drugs …
[HTML][HTML] Oxytocin in general anxiety and social fear: a translational approach
ID Neumann, DA Slattery - Biological psychiatry, 2016 - Elsevier
The neuropeptide oxytocin (OXT) has been revealed as a profound anxiolytic and antistress
factor of the brain, besides its many prosocial and reproductive effects. Therefore, there is …
factor of the brain, besides its many prosocial and reproductive effects. Therefore, there is …
Neurobiology of fear and specific phobias
R Garcia - Learning & memory, 2017 - learnmem.cshlp.org
Fear, which can be expressed innately or after conditioning, is triggered when a danger or a
stimulus predicting immediate danger is perceived. Its role is to prepare the body to face this …
stimulus predicting immediate danger is perceived. Its role is to prepare the body to face this …