Rat brain tumor models have been widely used in experimental neuro-oncology for almost
three decades. The present review, which will be selective rather than comprehensive, will …

G207 is a multimutated, conditionally replicating herpes simplex virus type 1 (HSV-1) that
retains an intact viral thymidine kinase (HSV-tk) gene. The virus exhibits oncolytic activity in …

Antitumor effects of herpes simplex virus-thymidine kinase (HSV-tk) gene transfer followed
by ganciclovir (GCV) administration were studied by serial magnetic resonance imaging …

The retrovirus vector containing Herpes simplex virus type 1 thymidine kinase (HSV/A-)
gene was constructed. The vector was transfected into the packaging cell line PG13. It was …

Success of medical treatments for any pathological disorders majorly depends on the
efficacy of the therapeutic molecules and their delivery to the target sites. Non-invasive …

With the growing interest in gene therapy of brain tumors, there is a major need for suitable
animal models that can be used to assess the efficacy of various approaches to genetically …

We have investigated clonal variations on the in vivo bystander effect of herpes simplex
virus-thymidine kinase (HSV-TK)/ganciclovir (GCV) system, using an intracranial tumor …

Мультиформная глиобластома является одной из наиболее агрессивных опухолей
человека. Несмотря на применение комбинированного подхода в лечении, которое …

Malignant glioma is the most frequently diagnosed brain tumour in adults. Despite of current
treatment strategies, these tumours almost invariably recur and the prognosis of these …