Monogenic diabetes includes several clinical conditions generally characterized by early-
onset diabetes, such as neonatal diabetes, maturity-onset diabetes of the young (MODY) …

Background The most common type of monogenic diabetes is maturity-onset diabetes of the
young (MODY), a clinically and genetically heterogeneous group of endocrine disorders that …

This review focuses on the human pancreatic islet—including its structure, cell composition,
development, function, and dysfunction. After providing a historical timeline of key …

Understanding the genetic factors of diabetes is essential for addressing the global increase
in type 2 diabetes. HNF1A mutations cause a monogenic form of diabetes called maturity …

Throughout the 20th and 21st centuries, the incidence of non-communicable diseases
(NCDs), also known as chronic diseases, has been increasing worldwide. Changes in …

Background Maturity-onset diabetes of the young (MODY) is the most common type of
monogenic diabetes, being characterized by beta-cell disfunction, early onset, and …

Hepatocyte Nuclear Factor 4 (HNF4) is a transcription factor (TF) belonging to the nuclear
receptor family whose expression and activities are restricted to a limited number of organs …

Diabetes mellitus (DM) is a chronic metabolic condition characterized by persistent
hyperglycemia due to insufficient insulin levels or insulin resistance. Despite the availability …

Aberrant glucose homeostasis is the most common metabolic disturbance affecting one in
ten adults worldwide. Prediabetic hyperglycemia due to dysfunctional interactions between …

The beta-cell identity gene, pancreatic duodenal homeobox 1 (Pdx1), plays critical roles in
many aspects of the life of beta-cells including differentiation, maturation, function, survival …