Chronic disability after stroke represents a major unmet neurologic need. ReNeuron's
development of a human neural stem cell (hNSC) therapy for chronic disability after stroke is …

Cell-identity switches, in which terminally differentiated cells are converted into different cell
types when stressed, represent a widespread regenerative strategy in animals, yet they are …

Hypoxia is a hallmark of various ischemic diseases such as ischemic heart disease,
ischemic limb, ischemic stroke, and solid tumors. Gene therapies for these diseases have …

Maintaining long-term euglycemia after intraportal islet transplantation is hampered by the
considerable islet loss in the peri-transplant period attributed to inflammation, ischemia and …

The mechanisms that restrict regeneration and maintain cell identity following injury are
poorly characterized in higher vertebrates. Following β-cell loss, 1–2% of the glucagon …

Regenerative medicine appears to take as its patron, the Titan Prometheus, whose liver was
able to regenerate daily, as the field attempts to restore lost, damaged, or aging cells and …

Angiogenesis is one of the essential processes that occur during wound healing. It is
responsible for providing immunity as well as the regenerative cells, nutrition, and oxygen …

Aims/hypothesis Hypoxia in the initial days after islet transplantation leads to considerable
loss of islet mass and contributes to disappointing outcomes in the clinical setting. The aim …

Introduction Stroke is the most common cause of neurological disability in adults worldwide.
Neural stem cell (NSC) transplantation has shown promising results as a treatment for stroke …

Endothelial cells represent one of the most abundant and widely found cell types in the
mammalian embryo. These cells arise in close proximity with and often as an integral part of …