The increase in life expectancy has boosted the incidence of age-related pathologies
beyond social and economic sustainability. Consequently, there is an urgent need for …

Polycystic ovary syndrome (PCOS) is an endocrine disorder, afflicting females of
reproductive age. This syndrome leads to infertility, insulin resistance, obesity, and …

Inter and intra-tumoral heterogeneity are major stumbling blocks in the treatment of cancer
and are responsible for imparting differential drug responses in cancer patients. Recently …

Metformin, one of the oldest oral antidiabetic agents and still recommended by almost all
current guidelines as the first-line treatment for type 2 diabetes mellitus (T2DM), has become …

Objectives In this study, we aim to determine the effect of metformin on osteoarthritis (OA)
development and progression. Methods Destabilisation of the medial meniscus (DMM) …

The epidemic of the century, Diabetes Mellitus (DM) is continuously rising. Intensive
research is urgently needed whereby experimental models represent an essential tool to …

Long-term exposure to crystalline silica particles leads to silicosis characterized by
persistent inflammation and progressive fibrosis in the lung. So far, there is no specific …

Abstract Type 1 diabetes (T1D) is an autoimmune disease caused by the destruction of the
insulin‐producing β‐cells within the pancreas. Islet transplantation represents one cure; …

The present study aimed to explore the renoprotective effect of metformin on diabetic
nephropathy in type 2 diabetic rats. A rat model of type 2 diabetic nephropathy (T2DN) was …

Pumpkin polysaccharide is able to alleviate diabetes, but understanding of the underlining
mechanism is still limited. In this study, we hypothesized that the alleviating effects of …