The gut microbiota represents a 'metabolic organ'that can regulate human metabolism. Intact
gut microbiota contributes to host homeostasis, whereas compositional perturbations …

Evidence suggests that gut microbiota composition and diversity can be a determinant of
skeletal muscle metabolism and functionality. This is true in catabolic (sarcopenia and …

Aging promotes most degenerative pathologies in mammals, which are characterized by
progressive decline of function at molecular, cellular, tissue, and organismal levels and …

Sarcopenia, characterized by loss of skeletal muscle mass, quality, and strength, has
become a common hallmark of ageing and many chronic diseases. Diabetes mellitus …

Objective Osteoporosis is associated with senescence of bone marrow mesenchymal stem
cells (BMSCs). Extracellular vesicles derived from senescent BMSCs (BMSC-EVs) could be …

Sarcopenia and obese sarcopenia are increasingly prevalent chronic diseases with
multifactorial pathogenesis, and no approved therapeutic drug to date. In the established …

With the global increase of the elderly population, the improvement of the treatment for
various aging-related diseases and the extension of a healthy lifespan have become some …

The progressive loss of skeletal muscle mass and concomitant reduction in contractile
strength plays a central role in frailty syndrome. Age-related neuronal impairments are …

Sarcopenia, an age-related disease characterized by loss of muscle strength and muscle
mass, has attracted the attention of medical experts due to its severe morbidity, low living …

Background Dissection of the regulatory pathways that control skeletal muscle development
and atrophy is important for the treatment of muscle wasting. Long noncoding RNA (lncRNA) …