Lysosomes serve as the cellular recycling centre and are filled with numerous hydrolases
that can degrade most cellular macromolecules. Lysosomal membrane permeabilization …

Apoptosis is a physiological cell suicide program that is critical for the development and
maintenance of healthy tissues. Dysregulation of cell death pathways occur in cancer …

Neutrophil granule serine proteases contribute to immune responses through cleavage of
microbial toxins and structural proteins. They induce tissue damage and modulate …

The discovery of a novel proteolytic network in the cytosol of metazoan cells comes as a
surprise to a field that previously considered intracellular proteolysis to mainly be a …

Apoptotic cell death is executed by the caspase-mediated cleavage of various vital proteins.
Elucidating the consequences of this endoproteolytic cleavage is crucial for our …

Lysosomes are the key degradative compartments of the cell. Lysosomal cathepsins, which
are enclosed in the lysosomes, help to maintain the homeostasis of the cell's metabolism by …

The death morphology commonly known as apoptosis results from a post-translational
pathway driven largely by specific limited proteolysis. In the last decade the structural basis …

Caspases are a large family of evolutionarily conserved proteases found from
Caenorhabditis elegans to humans. Although the first caspase was identified as a …

Apoptosis is orchestrated by the concerted action of caspases, activated in a minimal two-
step proteolytic cascade. Existing data suggests that apical caspases are activated by …

Members of the caspase family of proteases transmit the events that lead to apoptosis of
animal cells. Distinct members of the family are involved in both the initiation and execution …