DNA damage can alter nucleotide sequences and lead to expression of dysfunctional
proteins that impact normal cellular physiology. Sources of DNA damage can be …

DNA is vulnerable to damage resulting from endogenous metabolites, environmental and
dietary carcinogens, some anti-inflammatory drugs, and genotoxic cancer therapeutics …

DNA damage created by endogenous or exogenous genotoxic agents can exist in multiple
forms, and if allowed to persist, can promote genome instability and directly lead to various …

Alkylating agents constitute a major class of frontline chemotherapeutic drugs that inflict
cytotoxic DNA damage as their main mode of action, in addition to collateral mutagenic …

DNA damaging agents are potent inducers of cell death triggered by apoptosis. Since these
agents induce a plethora of different DNA lesions, it is firstly important to identify the specific …

Over the last decades, the growing understanding on DNA damage response (DDR)
pathways has broadened the therapeutic landscape in oncology. It is becoming increasingly …

The DNA repair enzyme O6-methylguanine-DNA methyltransferase (MGMT) is commonly
overexpressed in cancers and is implicated in the development of chemoresistance. The …

Glioblastoma is the most common primary malignant brain tumor. Although current standard
therapy extends median survival to~ 15 months, most patients do not have a sustained …

Single-cell analysis of the DNA repair protein is important but remains unachieved.
Exploration of nanopipettte technologies in single-cell electroanalysis has recently seen …

Alkylating agents have been used since the 60ties in brain cancer chemotherapy. Their
target is the DNA and, although the DNA of normal and cancer cells is damaged …