Nuclear factor erythroid 2-related factor 2 (NRF2) is a transcription factor that regulates the
cellular defense against toxic and oxidative insults through the expression of genes involved …

The transcription factor NF-E2 p45-related factor 2 (NRF2; encoded by NFE2L2) and its
principal negative regulator, the E3 ligase adaptor Kelch-like ECH-associated protein 1 …

Environmental pollution is one of the most serious challenges to health in the modern world.
Pollutants alter immune responses and can provoke immunotoxicity. In this Review, we …

Systems medicine has a mechanism-based rather than a symptom-or organ-based
approach to disease and identifies therapeutic targets in a nonhypothesis-driven manner. In …

T lymphocytes rely on several metabolic processes to produce the high amounts of energy
and metabolites needed to drive clonal expansion and the development of effector functions …

Oxidative stress is a major component of cell damage and cell fat, and as such, it occupies a
central position in the pathogenesis of metabolic disease. Nuclear factor-erythroid-derived 2 …

Chronic kidney disease (CKD) is one of the fastest-growing causes of death and is predicted
to become by 2040 the fifth global cause of death. CKD is characterized by increased …

Autism is a neurodevelopmental disease which is characterized by its core behavioral
symptoms such as impairment in social interaction and stereotyped repetitive behavior …

Rheumatoid arthritis is a systemic autoimmune disease with pain and functional disorder of
joints. Multiple strategies toward treatment of the rheumatoid arthritis are operating, while …

Abstract Nuclear factor (erythroid-derived 2)-like 2 (Nrf2) is a master regulator of cellular
protective processes. Rheumatic diseases are chronic conditions characterized by …