Effects of medicinal plants and phytochemicals in Nrf2 pathways during inflammatory bowel diseases and related colorectal cancer: A comprehensive review

LF Laurindo, MC de Maio, G Minniti, N de Góes Corrêa… - Metabolites, 2023 - mdpi.com
Inflammatory bowel diseases (IBDs) are related to nuclear factor erythroid 2-related factor 2
(Nrf2) dysregulation. In vitro and in vivo studies using phytocompounds as modulators of the …

Nrf2 as a therapeutic target for rheumatic diseases

ML Ferrándiz, J Nacher-Juan, MJ Alcaraz - Biochemical Pharmacology, 2018 - Elsevier
Abstract Nuclear factor (erythroid-derived 2)-like 2 (Nrf2) is a master regulator of cellular
protective processes. Rheumatic diseases are chronic conditions characterized by …

Mitochondria as a key player in systemic lupus erythematosus

DC Quintero-González, M Muñoz-Urbano… - Autoimmunity, 2022 - Taylor & Francis
Systemic lupus erythematosus (SLE) is a heterogeneous, multisystemic autoimmune
disease with a broad clinical spectrum. Loss of self-tolerance and chronic inflammation are …

Clinical research progress of small molecule compounds targeting Nrf2 for treating inflammation-related diseases

Z Zhai, Y Huang, Y Zhang, L Zhao, W Li - Antioxidants, 2022 - mdpi.com
Studies have found that inflammation is a symptom of various diseases, such as coronavirus
disease 2019 (COVID-19) and rheumatoid arthritis (RA); it is also the source of other …

Jieduquyuziyin prescription promotes the efficacy of prednisone via upregulating Nrf2 in MRL/lpr kidneys

L Du, Y Feng, C Wang, X Shi, C Wen, Z He… - Journal of …, 2022 - Elsevier
Abstract Ethnopharmacological relevance The Jieduquyuziyin prescription (JP), a traditional
Chinese medicine (TCM) formula, has been used as an approved hospital prescription to …

[HTML][HTML] CD200R1 promotes interleukin-17 production by group 3 innate lymphoid cells by enhancing signal transducer and activator of transcription 3 activation

H Linley, A Ogden, S Jaigirdar, L Buckingham, J Cox… - Mucosal …, 2023 - Elsevier
Psoriasis is a common chronic inflammatory skin disease with no cure. It is driven by the
interleukin (IL)-23/IL-17A axis and type 17 T helper cells; however, recently, group 3 innate …

Oleocanthal supplemented diet improves renal damage and endothelial dysfunction in pristane-induced systemic lupus erythematosus in mice

T Montoya, M Sánchez-Hidalgo, ML Castejón… - Food Research …, 2023 - Elsevier
Systemic lupus erythematosus (SLE) is a multiorgan disorder with a deregulated immune-
inflammatory response. Nutritional therapy has been considered a promising approach to …

Oxidative stress in SLE T cells, is NRF2 really the target to treat?

K Ohl, K Tenbrock - Frontiers in Immunology, 2021 - frontiersin.org
Oxidative stress is a major component of cellular damage in T cells from patients with
systemic lupus erythematosus (SLE) resulting amongst others in the generation of …

Xiehuo Xiaoying decoction inhibits Tfh cell expansion and promotes Tfr cell amplification to ameliorate Graves' disease

P Xiang, Y Zhang, X Qu, Y Chen, Y Xu, X Li… - Journal of …, 2023 - Elsevier
Abstract Ethnopharmacological relevance Xiehuo Xiaoying decoction (XHXY) has shown
great potential in the treatment of GD, but its mechanism remains obscure. Increase of …

Association of serum Nrf2 protein levels with disease activity and renal impairment in lupus nephritis

J Li, Q Guo, X Wei, Y Zhu, M Luo, P Luo - Frontiers in Immunology, 2024 - frontiersin.org
Introduction We aimed to investigate the relationship between nuclear factor erythroid 2-
related factor 2 (Nrf2) protein expression levels, lupus nephritis (LN) disease activity, and the …