There is an urgent need for improved diagnostics and therapeutics for acute ischemic stroke.
This is the focus of numerous research projects involving in vitro studies, animal models and …

Introduction Restoration of blood flow following ischemic stroke can be achieved by means
of thrombolysis or mechanical recanalization. However, for some patients, reperfusion may …

Angiogenesis, the growth of new blood vessels, is a natural defense mechanism helping to
restore oxygen and nutrient supply to the affected brain tissue following an ischemic stroke …

The dynamics of BBB permeability after AIS in humans are not well understood. In the
present study we measured the evolution of BBB permeability after AIS in humans using …

Background and Purpose—With the advent of thrombolytic therapy for acute stroke,
reperfusion-associated mechanisms of tissue injury have assumed greater importance. In …

The blood–brain barrier (BBB) is the principal regulator of blood-borne substance entry into
the brain parenchyma. Therefore, BBB leakage, which leads to cerebral edema and influx of …

The chemokine CCL2 is considered as one of the main effectors driving postischemic
infiltration of monocytes into the brain parenchyma. New experimental data, however …

Background More than 80% of public-access defibrillation attempts do not result in
sustained return of spontaneous circulation in patients who have had an out-of-hospital …

The serine proteases tissue plasminogen activator, plasmin, and thrombin and their
receptors have previously been suggested to contribute to neuronal damage in certain …

Hypertension is a major risk factor for stroke, but the factors that contribute to the increased
incidence and severity of ischemic stroke in hypertension remain to be determined. 20 …